混合稀土常乐对肾脏超微结构的影响  

Effect of the mixed rare earth changle on ultrastructure of wistar rat's kidney

作　　者：郝利铭[1] 姜文华[1] 董智勇[1] 陈爱军[1] 

机构地区：[1]吉林大学基础医学院组织学与胚胎学教研室,长春130021

出　　处：《陕西医学杂志》2006年第7期771-772,F0003,共3页Shaanxi Medical Journal

基　　金：国家自然科学基金资助项目(29890280-3)

摘　　要：目的:研究长期服用混合稀土常乐对肾脏超微结构的影响。方法:健康W istar大鼠120只,随机分成对照组和2m g/kg体重、5m g/kg体重和20m g/kg体重三个剂量的实验组,每天给药1次,每周6d给药,第7d休息,连续给药90d,第91d处死动物,取肾组织制作超薄切片,电子显微镜观察并摄影。结果:2m g/kg体重剂量组滤过膜的厚度均匀,但足细胞次级突起发生融合;5m g/kg体重剂量组滤过膜厚度不均匀,足细胞次级突起融合增多;20m g/kg体重剂量组滤过膜不规则且厚度不均匀,足细胞次级突起融合较多。结论:混合稀土常乐对肾脏滤过膜的结构有影响,5 m g/kg体重和20 m g/kg体重的剂量对滤过膜结构较为明显。Objcetive： To investigate effects of Changle, a mixed rare earth, on ultrastructure of Wistar rat＇s kidney. Methods： 120 healthy Wistar rats were divided into control group and experiment group＇; randomly. Changle was administered once a day for 6 days in a week, and totally it for 90 days. In 91th day, the kidneys were taken, and observed with transmission electron microscope. Results： In 2mg/ kg group, thickness of filtration membrane was normal, and fewer secondary processes of podocyte were fused. In 5 mg/kg group, thickness of filtration membrane was not even, and more seconaary processes of podocyte were fused. In 20 mg/kg group, thickness of filtration membrane was not even and rule, and more secondary processes of podocyte were fused. Conclusion： Mixed rare earth Changle can affect the structure of filtration membrand of kidney, and the ultrastructure was affected obviously by the dose of 5 mg/kg and 20 mg/kg.

关 键 词：肾/超微结构 稀土元素/化学 大鼠 

分 类 号：R587.1[医药卫生—内分泌] R135.99[医药卫生—内科学]