妊娠糖尿病危险因素病例对照研究  

A case-control study on risk factors of gestational diabetes mellitus

作　　者：强兆艳[1] 王建华[1] 齐秀英[1] 

机构地区：[1]天津医科大学天津市生命科学中心实验室,天津300070

出　　处：《中国公共卫生》2006年第7期795-796,共2页Chinese Journal of Public Health

基　　金：国家自然科学基金(39970661)

摘　　要：目的 探讨妊娠糖尿病（GDM）的危险因素。方法 采用1：4配比病例对照研究方法。对行孕期健康检查的孕妇以问卷调查的方式收集现病史、孕产史、家族史、个人习惯、社会心理因素、父母情况等，并于首诊及孕24～48周进行体格检查和实验室检查，包括50g葡萄糖激发试验（GCT）和75g口服葡萄糖耐量试验（OGTT）实验等。结果 糖尿病家族史、父母患恶性肿瘤、孕前体质指数（BMI）、首诊腰髋比（WHR）、首诊股围与GDM的发生之间有统计学关联。OR值及其95％CI分别为6．930（1．840～26．105），13．804（1．552～122．75）。4．947（1．274～19．203），5．609（1．492～17．227）和6．269（1．867～21．045）。结论 有糖尿病家族史、父母患恶性肿瘤、孕前BMI〉26、WHR≥0．9、首诊股围〉60cm是GDM发生的危险因素。Objective To explore the risk factors of gestatinal diabetes mellitus（GDM）. Methods A hospital-based 1 ： 4 matched case-control study was conducted. Each case was matched with four controls on age. 21 GDM cases and 84 pregnant women without GDM were recruited. Information was collected through face-to-face interview, which included deographic data, disease history, disease family history, behavior pattern, social psychologic character, clinical data and laboratory data. Resuits Results from univariate conditional logistic regression analysis showed that GDM was associated with diabetic family history, family history of cancer, BMI, WHR and thigh circumference. The corresponding OR with 95% CI were 6. 930 （1.840- 26. 105）, 13. 804 （1.552 - 122.75）, 4. 947（1.274- 19. 203）, 5. 069（1.492 - 17. 227） and 6. 269 （1.867 21. 045） respectively. Conclusion Diabetic family historty, family history of cancer, BMI 〉 26, WHR≥0.9 and thigh circumference〉60 cm were associated with higher risk for the development of GDM.

关 键 词：妊娠糖尿病 危险因素 病例对照研究 条件LOGISTIC 回归分析 

分 类 号：R587.1[医药卫生—内分泌]