金翘感冒口服液的质量标准研究  

Study on quality standard of Jinqiao Ganmao Koufuye

作　　者：王芳[1] 申屠少婷[2] 

机构地区：[1]广东省江门市中心医院药剂科,广东江门529030 [2]浙江大学医学院附属妇产科医院,杭州310006

出　　处：《中国现代应用药学》2006年第3期231-234,共4页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的研究金翘感冒口服液的质量标准。方法对金翘感冒口服液中主要药物金银花、连翘、甘草进行薄层色谱鉴别；采用RP-HPLC法测定绿原酸的含量。结果薄层色谱检出绿原酸、连翘药材、甘草次酸特征斑点，绿原酸进样量在0．224—1．120μg线性关系良好，平均加样回收率99．81％，RSD为0．89％。结论方法简便易行，灵敏，结果准确，重现性好，可有效控制金翘感冒口服液的质量。OBJECTIVE To study the quality standard of Jinqiao Ganmao Koufuye. METHODS TLC was applied to identify Flos Lontcerae Japonicae, Fructus Forsythiae and Radix et Rhizoma Glycyrrhizae in this prescription, and chlorogenic acid content in Kofuye was determined by RP-HPLC. RESULTS The characteristic maculae of chlorogenic acid ,Fructus Forsythiae and Glycyrrhetinic acid were detected by TLC. The linear rang of chlorogenic acid 0.224 - 1. 120μg, and the average recovery was 99.82% ,RSD = 2.3% （ n = 5 ）. CONCLUSION The evaluation methods are simple, sensitive, accurate and reproducible, and can be used for the quality control of this medicine.

关 键 词：金银花 连翘 甘草 绿原酸 高效液相色谱法 

分 类 号：R926.23[医药卫生—药学]