尿促性素治疗耐克罗米芬多囊卵巢综合征不孕症患者的临床观察  

Clinical study of HMG in the treatment of polycystic ovary syndrome related infertility with clomiphene resistance

作　　者：郑彤彤[1] 陈丽君[1] 冯云 

机构地区：[1]浙江省台州市中心医院妇产科不孕不育专科门诊,浙江台州318000 [2]上海瑞金医院生殖医学中心,上海200135

出　　处：《中国现代应用药学》2006年第3期246-248,共3页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的评估尿促性素(HMG)序贯低剂量方案治疗多囊卵巢综合征(PCOS)耐克罗米芬(CC)无排卵不孕症的有效性和安全性。方法对45例耐CC的PCOS不孕症患者进行66个周期HMG序贯低剂量方案促排卵治疗,以阴道B超和血雌二醇(E2)水平作为监测卵泡发育的指标。结果除3例因卵泡发育数目大于10个而中止、1例卵泡不发育而放弃外,余周期均排卵,15个周期为单卵泡发育。其中20例单胎妊娠,4例双胎妊娠,1例多胎妊娠而减胎成双胎。无重度卵巢过度刺激综合征(OHSS)发生,无局部及全身不良反应。结论HMG序贯低剂量方案是治疗耐CC的PCOS无排卵不孕症有效而安全的排卵选择。适时准确的阴道B超是适时调整剂量减少治疗中止、防止OHSS的有效措施。OBJECTIVE To assess the efficacy and safety of sequential low dose human menopausal gonadotropins （HMG） protocol in ovulation induction of polycystic ovary syndrome related infertile patients with clomiphene （CC） resistance. METHODS Fortyfive PCOS related infertile patients with CC resistance were enrolled for ovulation induction by sequential low dose HMG protocol, using urinary HMG （Menotrophin） 66 cycles. Follicular development was monitored by transvaginal ultrasonography and serum estradiol （E2） detection. RESULTS 62 out of 66 cycles ovulated, among them 15 had monofollicle development. 20 patient achieved single pregnancy, 4 twin and 1 multiple gestation. No severe ovarian hyperstimulation syndrome （ OHSS）, local or systemic side effect was seen. CONCLUSION Sequential low dose HMG protocol is an effective and safe choice in inducing ovulation for CC-resistant PCOS infertile case. Transvaginal ultrasonography is important for appropriate dose adjustment and avoidance of cancellation or OHSS.

关 键 词：多囊卵巢综合征 不孕症 尿促性素 排卵诱导 妊娠 

分 类 号：R711.75[医药卫生—妇产科学] R711.6[医药卫生—临床医学]