高原枪弹伤对伤道肌肉组织酶活性和物质消耗的影响  

Changes of enzyme activity and material consumption in muscular tissues of wound track after gunshot wound in a simulated war environment at high altitude

作　　者：殷作明[1] 李素芝[1] 胡德耀[2] 叶峰[1] 杨志焕[2] 石权贵[1] 何代平[1] 宋俊[1] 刘良明[2] 刘安[1] 汤建林[1] 

机构地区：[1]西藏军区总医院骨科,西藏拉萨850003 [2]第三军医大学大坪医院野战外科研究所创伤烧伤和复合伤国家重点实验室,重庆400042

出　　处：《创伤外科杂志》2006年第4期293-296,共4页Journal of Traumatic Surgery

基　　金：军队"十五"指令性课题资助项目(01L008)

摘　　要：目的探讨高原平战时枪弹伤对猪伤道肌肉组织酶活性和物质消耗的影响。方法将24头实验猪随机分为高原战时致伤组(GZ组)、高原平时致伤组(GP组)和平原平时致伤组(PP组),分别于伤前、伤后不同时相点取伤道周围肌肉组织匀浆,定量测定Na+-K+-ATP酶、乳酸脱氢酶(LDH)、磷酸肌酸激酶(CK)、肌糖原(MG)、乳酸(LA)、游离无机磷(P i3+)的含量。结果(1)PP组伤后伤道肌肉组织酶活力降低和物质消耗的程度最轻、发生晚、恢复早而快;(2)GP组伤后伤道肌肉组织酶活力降低和物质消耗程度>PP组而<GZ组;(3)GZ组伤后伤道肌肉组织酶活力降低和物质消耗程度显著大于GP组,且出现早、恢复慢。结论高原猪肢体枪弹伤后,各组伤道肌肉组织酶活力降低和物质消耗的程度依次为:GZ>GP>PP。因此,对高原枪弹战伤应注意对机体各种营养物质的补充和酶活力的保护。Objective To investigate the changes of material consumption and enzyme activity in the muscular tissues of the wound track after gunshot wound in pig at high altitude. Methods Twenty-four pigs,divided into normal environment group （ PP, n = 8 ）, high altitude group （ GP, n = 8 ）, and high altitude with war environment group （ GZ,n = 8 ）. Gunshot wound in the posterior limbs were induced in different environments. The content of Na^＋- K^＋ -ATPase,LDH,CK,MG,LA,Pi^3＋ in the muscular tissues of the wound track was measured at different time after injury. Results The changes of the consumption of MG, LA, Pi^3＋ and enzyme activity in the muscular tissues of the wound track of PP group was morderate as compared with that of GP and GZ group,and that of GZ group was severer than that of GP group. Conclusion The changes of enzyme activity and MG, LA, Pi^3＋ in the muscular tissues of the wound track is GZ group 〉 GP group 〉 PP group. Much attention should be paid to the nourishment of organism and protection of enzyme activity after gunshot injury at altitude.

关 键 词：高原 枪弹伤 酶活性 

分 类 号：R641[医药卫生—外科学] R826.5[医药卫生—临床医学]