中药人工周期疗法配合辅助生育技术对体外受精胚胎种植率的影响  

Effect of Artificial Menstrual Cycle Induction by Chinese Medicine Combined with Assisted Reproductive Techniques on Embryo Implantation Rate in In-vitro Fertilization

作　　者：黄舒娥[1] 

机构地区：[1]广州市妇婴医院生殖中心,广州510180

出　　处：《广州中医药大学学报》2006年第4期302-304,共3页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：广州市卫生局科研基金课题(编号:2005A033)

摘　　要：【目的】探讨辅助生育技术结合中药人工周期疗法对体外受精胚胎种植率的影响。【方法】将69例不孕患者随机分为对照组（39例）和试验组（30例）。对照组采用单纯辅助生育技术，试验组在中药人工周期疗法2～3个疗程后采用辅助生育技术。中药人工周期方案根据月经周期中卵巢的“卵泡发育成熟、排卵、黄体形成、黄体萎缩”的周期性变化相应采取“补肾-活血化瘀-补肾-活血调经”的中药治疗。比较两组促卵泡激素的用药时间和剂量、获卵数、受精率、卵裂率、优质胚胎率、胚胎种植率和妊娠率。【结果】试验组的胚胎种植率为27．0％，明显高于对照组的15．0％（P〈0．01）；试验组的妊娠率和获卵数亦高于对照组（P〈0．01或P〈0．05），其他指标两组之间无显著性差异（P〉0.05）。【结论】在采取辅助生育技术前运用中药人工周期疗法有助于患者整体机能的改善和协调，从而提高胚胎种植率。[ Objective] To observe the effect of therapy of artificial menstrual cycle induction by Chinese medicine combined with assisted reproductive techniques （ART） on embryo implantation rate in in-vitro fertilization. [Methods] Sixty-nine infertility patients were randomized into groups A （ n = 30） and B （ n = 39）. Group B was treated with simple ART and group A received ART treatment after artificial menstrual cycle induction by Chinese medicine for 2 ～ 3 treatment courses. The therapy of artificial menstrual cycle induced by Chinese medicine respectivdy was carried out by applying Chinese medicine respectively with the actions of tonifying kidney, activating blood and removing stasis, tonifying kidney, and activating blood and regulating menstruation according to the ovarian cyclic changes of maturation of follicle, ovulation, formation of corpus luteum and atrophy of corpus luteum. After treatment, the medication time and dosage of gonadotropin, the number of retrieved oocytes, fertilization rate, cleavage rate, the number of fine quality embryo, embryo implantation rate and pregnancy rate were compared between the two groups. [ Results] In group A, the embryo implantation rate was 27.0%, higher than 15.0% in group B （P 〈0.01） ; pregnancy rate and the number of retrieved oocytes were also higher than those in group B （ P 〈 0.01 or P 〈 0.05 ）. No significant difference was found in other indexes between the two groups （P 〉 0.05）. [Conclusion] Therapy of artificial menstrual cycle induction by Chinese medicine combined with ART is helpful for the improvement and coordination of organic function, and thus increase embryo implantation rate in infertility patients.

关 键 词：辅助生育技术 受精 体外 不孕症/中药疗法 补肾药/治疗应用 活血祛瘀药/治疗应用 

分 类 号：R271.9[医药卫生—中西医结合]