清热化湿消瘀法对兔主动脉粥样硬化形成干预作用的超微结构研究  

Effects of Heat-clearing,Dampness-resolving and Stasis-removing Therapy on Aortic Ultrastructure of Rabbits with Atherosclerosis

作　　者：杨开清[1] 林培政[2] 

机构地区：[1]广州中医药大学第一附属医院,广州510405 [2]广州中医药大学,广州510405

出　　处：《广州中医药大学学报》2006年第4期318-321,共4页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：广东省教育厅资助项目(编号:0113)

摘　　要：【目的】探讨湿热证与动脉粥样硬化的关系以及清热化湿消瘀法的干预作用。【方法】以高脂饮食联合内毒素静脉注射法复制出湿热证兔模型,通过光镜和电镜观察该模型兔主动脉粥样硬化的形成情况及清热化湿消瘀法的干预效果。【结果】与空白对照组比较,湿热模型组兔呈现明显的动脉粥样硬化特征性改变,包括动脉内膜损伤、粥样斑块形成、泡沫细胞形成、平滑肌细胞增生等,经清热化湿消瘀法干预后上述病变明显改善。【结论】湿热内蕴化瘀致动脉粥样硬化的病机观有充分的形态学证据支持,清热化湿消瘀法对动脉粥样硬化具有干预效果。[ Objective] To explore the relationship between damp-heat syndrome （DHS） and aortic atheroslerosis （AA）, and to observe the effect of heat-clearing, dampness-resolving and stasis-removing therapy on AA. [Methods] DHS rabbit models were established by feeding with fatty diet and intravenous injection of endotoxins. The development of AA were observed under light microscope and electron microscope to evaluate the effect of heat-clearing, dampnessresolving and stasis-removing therapy. [ Results ] Compared with the blank control group, an obvious atherosclerotic changes were showed in the model rabbits： injury of arterial intima, appearance of atherosclerotic plaque, formation of foam ceils and proliferation of smooth muscle ceils. After treatment, the above damages were relieved. [ Conclusion] There has histological evidence for the pathogenesis of internal retention of damp-heat causing blood stasis, and heatclearing, dampness-resolving and stasis-removing therapy is effective for AA.

关 键 词：动脉粥样硬化/中药疗法 动脉粥样硬化/超微结构 湿热证 疾病模型 动物 兔 

分 类 号：R285.5[医药卫生—中药学]