猫儿屎植物的化学成分及其药效学研究  

Chemical constituents and medical activity from Decaisnea

作　　者：孔杰[1] 

机构地区：[1]西北师范大学植物研究所

出　　处：《西北师范大学学报（自然科学版）》1996年第3期108-111,共4页Journal of Northwest Normal University(Natural Science)

基　　金：甘肃省教委科研资助;中国科学院昆明植物所国家重点植物化学实验室科研资助

摘　　要：首次从木通科猫儿屎（ＤｅｃａｉｓｎｅａｆａｒｇｅｓｉｉＦｒａｎｃｈ）中分离鉴定了１１种皂甙化合物．经光谱分析及化学方法鉴定，其中５种化合物为新化合物，分别命名为：ＤｅｃａｉｓｏｓｉｄｅＡ、Ｂ、Ｃ、Ｄ、Ｇ；另５种化合物为ＳａｐｏｎｉｎＰＧ、ＤｉｐｓａｃｏｓｉｄｅＢ、Ｋａｌｏｐａｎａｘ－ｓａｐｏｎｉｎＢ、Ｓａｐｏｎｉｎ１１、ＨｅｄｅｒａｓａｐｏｎｉｎＢ和ｓａｐｏｎｉｎＰＪ３．猫儿屎对小鼠移植性肿瘤Ｓ１８０（小白鼠肉瘤）、Ｈｅｐａ（肝癌）、Ｅｃ（艾氏病）的平均抑制率分别为４７．８０％、４１．４８％、４４．７１％，具有一定的抗肿瘤活性．Eleven chemical constituents were isolated from the stem of Decaisnes fang erii Franch.Five of them were identified as decaisosides A～E together with five known ones.Their structure were established by means of chemical and spectroscopic evidence.Its extracts showed antitumour activity against S180,Hepa and Ehrlich cells.The rate of inhibition is 47. 80%,41.48 %and 44.47% distinguishly.

关 键 词：木通科 猫儿尿 三萜皂式 抗肿瘤活性 

分 类 号：Q949.746.6[生物学—植物学]