生附片与不同品种贝母配伍的药效学比较研究  

Comparative Studies on Compatible Application of Aconitum Carmichaelii Debx.and Various Fritillariae Tuber

作　　者：杨庆[1] 聂淑琴[1] 翁小刚[1] 王宏洁[1] 何希荣[1] 黄璐琦[1] 

机构地区：[1]中国中医科学院中药研究所,北京100700

出　　处：《中国实验方剂学杂志》2006年第6期25-29,共5页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家重点基础研究发展规划项目资助(NO:G19990554)

摘　　要：目的:观察生附片与不同产地贝母单用及配伍(1∶1)应用药效学的差别,探讨中药“相反”药对配伍是否妨害治疗。方法:观察生附片与不同产地贝母配伍对大鼠体温,小鼠体温、胃排空、小肠推进及镇痛抗炎作用的影响。结果:1.生附片与浙贝母配伍连续给药12d后降低正常小鼠体温的作用较单用生附片显著减弱(P<0.05)。2.生附片与浙贝或松贝配伍对抗安痛定致大鼠体温降低比单用生附片作用显著(P<0.05或P<0.01);3.生附片和松贝配伍抑制胃排空作用较单用生附片显著(P<0.05);4.生附片与松贝母配伍抗胃溃疡作用较单用生附片组强;生附片与青贝配伍抗炎方面比单用生附片作用强。结论:生附片与不同品种贝母配伍在对动物体温、胃排空功能、抗胃溃疡、及抗炎方面药理作用的性质和强度依配伍的贝母品种不同而有不同程度改变,值得研究。To observe the pharmacodynamics on compatible application of Aconitum carmichaelii Debx. and various fritiUariae tuber to explain the counteractive mechanism of herbal counteractors. Methods： The effects of Aconitum carmichaelii Debx. and various fritillariae tuber on body temperature, gastric empting, intestine progradation, antiinflammatory and analgetie of mouse were observed. Results： 1. After administration of 12 days, Aconitum carmichaelii Debx. can significantly degrade body temperature in normal mouse, meanwhile, Aconitum carmichaelii Debx. matched with Bulbus Fritillariae Thunbergii can resist the degrading of temperature causd by Carmichaelii Debx （ P 〈 0.05 ） ; 2. Aconitum carmichaelii Debx. Combine used with Bulbus Fritillariae Thunbergii or FritiUaria sungbei Hsiao et K. C. Hsia can significatly increase body temperature in antondine model rat compared with single use of Aconitum carmichaelii Debx. （P 〈 0.05 or P 〈 0.01 ）;3. There is a significant difference in mouse gastric empting effect between Aconitum carmichaelii Debx.and FritiUaria sungbei Hsiao et K. C. Hsia single use of and combinal one （ P 〈 0.05） ;4. Aconitum carmichaelii Debx. matched with F. unibracteata Hsiao et K. C. Hsia or F. przewalskii Maxing in anti-gastrohelcoma or anti-inflammatory showed a more potential action than Aconitum carmichaelli Debx. singly used. Conclusion：Pharmacologic effects of compatible application of Aconitum carmichaelii Debx. and various fritillariae tuber on animals＇ body temperature, gastric emptying, anti-gastrohelcoma and anti-inflammatory are different in Aconitum carmichaelii Debx.matched with various fritillariae tuber, which is worthy of thinking highly.

关 键 词：生附片 贝母 配伍 胃排空 肠推进 抗炎 体温 

分 类 号：R285.5[医药卫生—中药学]