大鼠子宫肌瘤两种模型比较与免疫功能的相关性研究  

The Relation Between Immune Function and the Model of Hysteromyoma in Rat

作　　者：李建荣[1] 吴兰生[1] 张广平[1] 

机构地区：[1]中国中医科学院中药研究所,北京100700

出　　处：《中国实验方剂学杂志》2006年第7期24-27,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：科技部创新药物和中药现代化项目(2002AA2Z3225)

摘　　要：目的:比较雌激素和雌、孕激素合用所致大鼠子宫肌瘤模型与其免疫功能的相关性。方法:分别以雌激素和雌、孕激素肌肉注射造成大鼠子宫肌瘤模型,并在此模型上观察大鼠免疫器官,用流式细胞仪测定其T细胞表面分化群CD3、CD4和CD4/CD8的水平,用放射配体结合分析法测定雌激素受体水平。结果:雌、孕激素致大鼠子宫肌瘤模型表现出其免疫器官胸腺重量降低;CD3、CD4和CD4/CD8明显降低,CD8明显升高;雌激素及其受体水平升高。结论:雌、孕激素致子宫肌瘤模型大鼠表现为免疫功能明显低下,雌激素受体水平是其主要影响因素之一。Objective：The relation between immune function and the model of hysteromyoma of rat were studied. Method： Rats were injected with diethyl 1 stilbestrol, and progesterone and diethyl stilbestrol together. The immune organs were observed,levels of CD3, CD4 and CD4/CD8 in serum were measured by flow cytometer;estrogen receptor was analyzed by radioligand combination assay. Result：Compared with normal group, the weight of thymus, the levels of CD3, CD4 and CD4/CD8 of model group injected with diethyl stilbestrol and progesterone was significantly increased. Conclusion： It is suggested that the low immunologic functions in model rats with estrogen and progesterone together was lower, might be related to the levels of estrogen receptor.

关 键 词：子宫肌瘤模型 免疫功能 CD-细胞 雌激素受体 大鼠 

分 类 号：R285.5[医药卫生—中药学]