药源性锥体外系反应2265例文献分析  

Drug-induced Extrapyramidal Syndrome:Analysis of 2265 Cases

作　　者：陈丽芳[1] 杨继章[2] 

机构地区：[1]天津市海河医院,天津市300350 [2]河北医科大学第一医院,石家庄市050031

出　　处：《中国药房》2006年第13期1008-1009,共2页China Pharmacy

摘　　要：目的：探讨药物引起锥体外系反应的特点及一般规律。方法：对1995年1月～2005年6月国内医药期刊报道的药源性锥体外系反应2265例进行统计、分析。结果：不良反应涉及12类药物，以消化系统用药、抗精神失常药、抗过敏药为主，位居首位的是甲氧氯普胺，共1626例（71．79％）。结论：临床工作者应掌握引起锥体外系不良反应的药物分布规律，安全用药。OBJECTIVE： To discuss the general pattern and characteristics of drug - induced extrapyramidal syndrome （EPS） .METHODS： 2 265 cases of drug- induced EPS reported in domestic medical journals published from Jan.1995 to Jun .2005 were analyzed statistically. RESULTS：Altogether 12 drug categories were involved in the drug - induced EPS, leading the list were digestive system drugs,psychotolytic drugs and antiallergic drugs, in which metoclopramide ranked the first place, with 1 626 cases（71.79% ） .CONCLUSIONS： It is essential for clinical practitioners master the distribution patterns of drugs that induced EPS so as to promote medication safety.

关 键 词：药品不良反应 锥体外系反应 文献 分析 

分 类 号：R969[医药卫生—药理学]