吸毒人群高危行为与相关血源病原感染相关研究  

Investigation into the relationship between the high risk behavior of drug abusing population and HCV infection

作　　者：谢联智 陈曦[2] 胡薇[1] 边会珍 刘莉[1] 邢志惠 杨正宁[1] 梁姝[3] 张莉[2] 尹潞[2] 王君[2] 陈康林[1] 秦光明[3] 阮玉华[1] 邵一鸣 

机构地区：[1]西昌市皮肤病性病防治站,四川西昌615000 [2]中国疾病预防控制中心性病艾滋病预防控制中心和传染病预防控制国家重点实验室 [3]四川省疾病预防控制中心,四川成都610031

出　　处：《中国热带医学》2006年第7期1140-1142,共3页China Tropical Medicine

基　　金：卫生部艾滋病防治应用性研究项目(WA2003-13);国家十五科技攻关项目(2004BA719A01);国家自然科学基金项目(30571612和10501052)

摘　　要：目的 了解四川省凉山彝族自治州地区吸毒人群共用注射器具静脉吸毒方式和性行为与HCV、HIV和梅毒感染的关系。方法于2004年5～7月，从社区中招募吸毒人群调查其社会人口学特征、近3个月直接和间接共用注射器具静脉吸毒方式和近6个月性行为情况。采集血样进行HIV、HCV和梅毒抗体检测。结果在调查的451名吸毒人群中HCV和HIV感染率分别为64．1％（289／451）和15．1％（68／451），HIV和HCV混合感染率为14．4％（65／451）。口吸吸毒者和静脉吸毒者HCV感染率分别为17．3％（14／81）和74．3％（275／370）；多因素Logistic回归分析结果显示，与HCV感染关系有统计学意义的变量为近3个月内共用针头或注射器静脉吸毒（OR值为2．27；95％CI为1．41-3．66）和未结婚或同居（OR值为2、21；95％CI为1．45～3．36）。未见性行为因素对吸毒人群HCV感染的影响。结论四川省凉山彝族自治州吸毒人群HCV和HIV感染率高，应加强对共用注射器具静脉吸毒行为的干预。Objective To investigate patterns of sharing injection equipment associated with HCV infection among drug users in Xichang County of Sichuan, China. Methods From May to July, 2004, a cross - sectional survey was conducted for survey of socio - demographic characteristics, direct and indirect sharing of injection equipments in the past three months and sexual behaviors in the past six months among drug users. Blood samples were also collected for detection of antibodies against HCV, HIV and syphilis. Results A total of 451 subjects were surveyed. The prevalence of HCV and HIV was 64.1% （289/451 ） and 15.1% （68/451 ） among drug users, respectively. The prevalence of HCV and HIV co- infection was 14.4% （65/451）. However, 17.3% （14/81） and 74.3% （275/370） of HCV infection was found among sniffing drug users and injection drug users, respectively. Multivariate logistic regression analysis showed sharing of needle or syringe in the past three months （OR = 2.27;95 % CI, 1.41 - 3.66） and mari- tal status （OR = 2.21 ; 95 % CI, 1.45 - 3.36） was independent associated with HCV infection among drug users, respectively. Conclusion HCV and HIV prevalence was high among drug users in Xichang County of Sichuan Province and intervention on the bahevior of direct and indirect sharing injection equipments among drug users be strengthened.

关 键 词：静脉吸毒 共用注射器具 HCV HIV 性行为 

分 类 号：R512.91[医药卫生—内科学]