下肢深静脉血栓后综合征预防措施的临床研究  

Clinical study on the prevention of post-thrombotic syndrome in lower extremity deep venous thrombosis patients

作　　者：吴学君[1] 金星[1] 郭培明[1] 种振岳[1] 张十一[1] 张精勇[1] 辛绍伟[1] 

机构地区：[1]山东省立医院血管外科,山东济南250021

出　　处：《中国普通外科杂志》2006年第5期338-342,共5页China Journal of General Surgery

摘　　要：目的探讨下肢深静脉血栓形成(DVT)患者出院后继续抗凝治疗、使用弹力袜以及爱脉朗在血栓后综合征(PTS)防治中的价值。方法将经过抗凝、溶栓治疗后的5 8例(5 8条肢体)患者,分为对照组(1 5例)、治疗1组(抗凝+弹力袜2 4例)和治疗2组(抗凝+弹力袜+爱脉朗1 9例),通过随访,比较临床评分,评价3组的治疗效果。结果对照组PTS发生率明显高于治疗1组和治疗2组;从6个月开始,治疗1组和治疗2组临床评分明显低于对照组;出院后1年和1.5年治疗2组临床评分明显低于治疗1组。结论DVT患者出院后的抗凝、压力支持治疗及爱脉朗的应用对于减少血栓后遗症的发生有重要作用。Objective To assess the effect of anticoagulant drugs, elastic compression stockings （ECS）and Daflon on the prevetion of the post-thrombotic syndrome （PTS）. Methods Fifty-eight deep venous thrombosis （DVT） patients were divided into control group and treatment group Ⅰand Ⅱ. The control group （ n = 15 ） did not take anticoagulant drugs or the time of anticoagulant drug administration was less than l month , and the use of （ECS） was less than 3 months. The treatment group I （ n = 24 ） took warfarin for 6 months and the ECS were used in the follow-up time; the treatment group Ⅱ n = 19 ） , besides warfarin therapy and ECS, took Daflon for 12 months. All the patients were followed up, the general conditions were assessed with clinical score, and the therapeatic results of the 3 groups were assessed. Results The rate of PTS occurrence in control group was significantly higher than that in treatment group 1 and treatment group 2. At 6 months, the clinical score of treatment groups 1 and 2 was significantly lower than that of control group. At 1 and 1 . 5 years after discharge, the clinical score of treatment group 2 was significantly lower than that of treatment group 1. Conclusions The long-term comprehensive and systemic therapy （including warfarin, ECS and daflon ） for DVT could prevent PTS.

关 键 词：血栓性静脉炎/治疗 深静脉栓塞后综合征 下肢 静脉血栓形成 

分 类 号：R714.625[医药卫生—妇产科学]