穴位埋线、中药对慢性肾功能衰竭大鼠PTH及TGF-β_1的影响  

Effects of acupoint thread implantation and Chinese herb on PTH and TGF-β_1 in the rat of chronic renal failure

作　　者：陈坤支[1] 师晶丽[2] 吕明庄[3] 贺志光[3] 覃仁安[3] 

机构地区：[1]贵阳市妇幼保健院儿童医院中医科,贵州550003 [2]中山大学第五附属医院中医科 [3]贵阳医学院

出　　处：《中国针灸》2006年第7期511-514,共4页Chinese Acupuncture & Moxibustion

摘　　要：目的:探讨足三里穴位埋线、中药治疗慢性肾衰(CRF)的作用机制。方法:Platt肾大部切除法诱导CRF模型大鼠,然后分5组:假手术组、模型组、中药组、埋线组、埋线加中药组。治疗8w后,测定血清甲状旁腺素(PTH)、残肾组织细胞转化生长因子β1(TGF-β1)的表达、残肾组织丙二醛(MDA)含量、血清尿素氮(BUN)、肌酣(Scr)、尿蛋白及病理改变情况。结果:经穴位埋线、中药及穴位埋线加中药治疗后的CRF模型大鼠的上述指标呈良性转逆,特别是以穴位埋线加中药组疗效最明显。结论:穴位埋线和中药改善CRF的作用机制与降低PTH、抑制TGF-β1的表达、降低MDA含量、阻止肾脏纤维化病变有关。Objective To probe into the mechanisms of thread implantation at Zusanli（ST 36） and Chinese herbs in treatment of chronic renal failure（CRF）. Methods CRF rat model was made by Platt subtotal nephrectomy. They were divided into 5 groups, sham operation group, model group, Chinese herbs group, thread implantation group and thread implantation plus Chinese herbs group. After treatment of 8 weeks, serum parathyroid hormone （PHT）, transforming growth factor β1 （TGF-β1） expression in residual renal cells, malondialdehyde（MDA） content in the residual renal tissue, serum urea nitrogen（BUN） and creatinine（Scr）, protein in urine and pathological changes were investigated. Results The above indexes after treatment by thread implantation at acupoint, Chinese herbs, and acupoint thread implantation plus Chinese herbs showed begin reversion, especially, the most obviously improvement in the acupoint thread implantation plus Chinese herbs treatment group. Conclusion The mechanism of acupoint thread implantation and Chinese herbs in improvement of CRF is related with decrease of PTH, inhibition of TGF-β1 expression, decrease of MDA content and resisting lesion of renal fibrosis.

关 键 词：肾功能衰竭/穴位疗法 穴位埋线结扎 甲状旁腺素/代谢 转化生长因子/代谢 

分 类 号：R244.8[医药卫生—针灸推拿学]