离子液体中的Mannich反应研究  

Study on Mannich reaction in ionic liquids

作　　者：惠斌[1] 孟娜[1] 陈凤凰[1] 丁雄[1] 肖敏亮[1] 陈志娟[1] 郭保收[1] 唐文明[1] 

机构地区：[1]贵州大学精细化工研究开发中心

出　　处：《化学试剂》2006年第6期323-325,328,共4页Chemical Reagents

基　　金：贵州省优秀人才省长基金项目[(黔科技)2003(04)号]资助

摘　　要：研究了甲醛、芳香酮、脂肪胺盐酸盐3组分在离子液体[bmim]BF4中的Mannich反应,反应不需要加入任何路易斯酸或质子酸催化剂即可发生,且离子液体至少可以循环使用5次。同时还考察了芳香醛、芳香酮、芳香胺3组分在[bmim]BF4中的Mannich反应。β-Bromoethyl benzene （β-BEB） was synthesized by anti-Markovnikov addition of hydrogen bromide to styrene under ultraviolet light irradiation. The reaction conditions were studied by orthogonal experiments and gas chromatographic analysis of the product. Further experiments showed that the conversion of styrene was above 99% and the highest yield of β-BEB was above 93% under the conditions that the intensity of ultraviolet light was 0. 5mw/cm^2, the reaction time 60min, the reaction temperature 60℃ ,the volume of CC14 5 times of styrene. The purity of β-BEB reached 99% after refined by the addition of iron.

关 键 词：离子液体 MANNICH反应 脂肪胺盐酸盐 

分 类 号：O621.25[理学—有机化学]