Identification of four novel mutations in the HNF-1A gene in Chinese early-onset and/or multiplex diabetes pedigrees  

作　　者：YANG Zhen WU Song-hua ZHENG Tai-shan LU Hui-juan XIANG Kun-san 

机构地区：[1]Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, Shanghai No. 6 People＇s Hospital, Shanghai Jiaotong University, Shanghai 200233, China

出　　处：《Chinese Medical Journal》2006年第13期1072-1078,共7页中华医学杂志（英文版）

基　　金：This work was supported by grants from the National Natural Science Foundation of China (No. 30470813) Shanghai Scientific Committee (No. 02DJ14052-I).

摘　　要：Background Mutations in the hepatocyte nuclear factor-lA gene cause the type 3 form of maturity-onset diabetes of the young （MODY3）. This study was undertaken to determine mutations and sequence variations of the HNF-1A gene in Chinese with familial early-onset and/or multiplex diabetes mellitus.Background Mutations in the hepatocyte nuclear factor-lA gene cause the type 3 form of maturity-onset diabetes of the young （MODY3）. This study was undertaken to determine mutations and sequence variations of the HNF-1A gene in Chinese with familial early-onset and/or multiplex diabetes mellitus.

关 键 词：maturity-onset diabetes of the young hepatocyte nuclear factor-1A gene direct sequencing 

分 类 号：R587.1[医药卫生—内分泌]