大承气汤与甘寒生津法合用对土燥水竭证的影响  

Effect of Dachengqi Decoction Combined with the Treatment Principle of Promoting Production of Body Fluid with Sweet-Flavored and Cold-natured drugs on the Earth-dry and Water-exhaust Syndrome

作　　者：张喜奎[1] 赵先锋[2] 

机构地区：[1]福建中医学院教务处 [2]广西壮族自治区柳州市中医院

出　　处：《中医杂志》2006年第6期450-453,共4页Journal of Traditional Chinese Medicine

基　　金：福建省科技厅资助项目(2001J066);教育厅资助项目(A01079)

摘　　要：目的探讨大承气汤(急下存阴法)及其与甘寒生津法合用(甘寒攻下法)治疗土燥水竭证的作用机理。方法将青紫蓝家兔随机分为空白对照组、病理模型组、急下存阴治疗组及甘寒攻下治疗组4组,观察治疗前后各组家兔的症状、体征及脏器组织病理学改变,以及血白细胞(WBC)计数、一氧化氮(NO)、超氧化物歧化酶(SOD)、丙二醛(MDA)、中分子物质(MMS)、巯基(-SH)、钾(K+)、钠(Na+)及全血和血浆黏度等变化。结果两治疗组在降低模型动物体温,升高SOD、MMS、K+、Na+水平,降低NO、MDA、-SH及全血和血浆黏度等方面,与病理模型组比较差异均有显著性(P<0.05或P<0.01),甘寒攻下组与急下存阴组差异亦有显著性(P<0.05)。结论急下存阴法及甘寒攻下法均对土燥水竭证动物模型有良好的纠治作用,且后者效果优于前者。Objective： To probe the mechanism of Daehengqi Decoction combined with the treatment principle of promoting production of body fluid with sweet-flavored and cold-natured drugs on the earth-dry and water-exhaust syndrome. Methods ：Chinchilla Giganta rabbits were randomly divided into four groups, i. e. blank control group, pathological model group, timely purgation to preserve Yin treatment group and treatment group of purgation with drugs sweet in favor and cold in nature. Changes of symptoms,signs, pathological changes of organs, WBC count, nitric oxide （NO）, superoxide dismutase （SOD）, malondialdehyde （MDA）, middle molecular substanees（MMS）,sulfydryl（-SH）,K^＋ and Na^＋ ,and viscosities of whole blood and plasma before and after treatment were investigated. Results： There were significant differences in decrease of body temperature, increases of SOD, MMS, K^＋ and Na^＋, decreases of NO, MDA,-SH and viscosities of whole blood and plasma as the two treatment groups compared with the pathological model group（P〈0. 05 or P〈0.01）. There was also significant difference between the two treatment groups（P〈0. 05）. Conclusion：Both the timely purgation to preserve Yin method and the method for purgation with sweet-favored and coldnatured drugs have good corrective and therapeutic effect on the animal with the earth-dry and water-exhaust syndrome,the effect of the latter being superior to that of the former.

关 键 词：大承气汤/治疗应用 甘寒生津 @土燥水竭证 

分 类 号：R254[医药卫生—中医内科学]