扶正活血方对慢性肾功能衰竭大鼠血生长激素和胰岛素生长因子的影响  

Effects of Fuzheng Huoxue Recipe on Blood Growth Hormone and Insulin Growth Factor in Chronic Renal Failure Rats

作　　者：李均[1] 何立群[2] 李屹[2] 

机构地区：[1]遵义医学院第五附属医院中医科 [2]上海中医药大学附属曙光医院

出　　处：《中医杂志》2006年第6期456-458,共3页Journal of Traditional Chinese Medicine

基　　金：上海市科学技术发展项目(01DJ19013)

摘　　要：目的研究扶正活血方对慢性肾功能衰竭(CRF)大鼠血生长激素(GH)和胰岛素生长因子(IGF-1)的影响。方法应用Platt方法制作5/6肾切除CRF大鼠模型。根据模型制作成功后的血肌酐值,分为模型组、黄芪组、依那普利组、丹参组、扶正活血方组及正常对照组,观察扶正活血方对CRF大量蛋白尿大鼠GH和IGF-1的影响。结果模型对照组的GH和IGF-1明显高于正常组,扶正活血方药干预后,大鼠血GH和IGF-1水平明显降低。结论扶正活血方能降低CRF大鼠血GH和IGF-1水平,具有延缓CRF进展的作用。Objective：To observe effects of Fuzheng Huoxue Recipe on blood growth hormone （GH） and insulin growth factor （IGF-1） in chronic renal failure （CRF） rats. Methods：Platt method was adopted to make 5/6 kidney excision CRF model rat,and the rats were divided into model group ,Huangqi group ,Enalapril group ,Danshen group ,Fuzheng Huoxue Recipe group and normal control group according to the blood ereatinine level after modeling. Effects of Fuzheng Huoxue Recipe on GH and IGF-1 levels in CRF rats with large quantity of urinal protein were investigated. Results： GH and IGF-1 levels in the model control group were significantly higher than that in normal control group ,and after treatment of Fuzheng Huoxue Recipe ,blood GH and IGF-1 levels were significantly decreased. Conclusion ：Fuzheng Huoxue Recipe can decrease blood GH and IGF-1 levels in CRF rats,and can delay advances of CRF.

关 键 词：肾功能衰竭 慢性/中医药疗法 生长调节素类/药物作用 @扶正活血方 

分 类 号：R285[医药卫生—中药学]