抗精浆免疫抑制物抗体的抗生育机理研究  

Antifertility pathogenetic mechanism of anti-SPIM antibodies

作　　者：黄邱朝[1] 陈金俤 

机构地区：[1]南京军区南京总医院免疫科,解放军第92医院

出　　处：《中华泌尿外科杂志》1996年第12期755-757,共3页Chinese Journal of Urology

摘　　要：为了探讨抗精浆免疫抑制物抗体（ＳＰＩＭ－Ａｂ）的抗生育机理，对１００例不育症患者和３０例正常对照进行了ＳＰＩＭ－Ａｂ的补体结合功能测定（ＣＦＡ）和ＳＰＩＭ－Ａｂ对精子凝集、制动、穿透力和杀精子影响的研究。结果：ＳＰＩＭ－Ａｂ阳性不育患者（ｎ＝２９）ＣＦＡ值为６．４７±１．５５ｋＵ／Ｌ，明显低于ＳＰＩＭ－Ａｂ阴性患者（ｎ＝７１，８．１１±１．６２ｋＵ／Ｌ）和对照组（ｎ＝３０，８．６０±１．８０ｋＵ／Ｌ），Ｐ＜０．０１。经ＳＰＩＭ－Ａｂ阳性血清和ＳＰＩＭ－Ａｂ阴性血清作用后，两组精子凝集，制动和死精子百分率分别为４１．４％、２１．１％，６９．０％、１６．９％，６２．１％、４．２％，精子穿透高度分别为３１．６±１３．０ｍｍ、３８．０±１２．９ｍｍ，有显著性差异（Ｐ＜０．０５～Ｐ＜０．０１）。结论：ＳＰＩＭ－Ａｂ能够以抗原抗体复合物形式激活补体，对精子凝集、制动、杀伤和穿透力的影响是干扰生育的重要原因之一。To study the antifertility pathogenetic mechanism of antiseminal plasma inhibition material antibodies(SPIM-Ab),studies on complement fixation assay (CFA)of SPIM-Ab and effects of the latter upon sperm agglutination and mobility, sperm penetration ability and upon its sperm killing effect were caried out in 100 infertile males and in 30 normal controls, The level of CFA in infertile patients with positive SPIM-Ab(n=29,6.47 ±1. 55 kU/L)wars significantly lower than these with negative SPIM-Ab(n=71,8. 11 ±1. 62 kU/L), P<0.01 and also the controls(n=30,8.60 ±1.80kU/L), P<0.01.After acting by the SPIM-Ab positive serum, the positive rates of sperm agglutination, immobility and dead sperm were 41. 4%, 69. 0% and 62. 1% respectively while those were 21. 1%, 16. 9% and 4.296 when acting by SPIM-Ab negative serum.The sperm penetration height was 31.6 ±13. 0mm in the former group and 38.0±12. 9mm in the latter group. All these were significantly different between the SPIM-Ab positive and the SPIM-Ab negative groups(P<0.05～p<0.01). It was concluded that SPIM-Ab was able to effect sperm agglutination,mobility and penetration ability and there was a sperm killing effect. SPIM-Ab was therefore one of the important factors that might cause infertility in male.

关 键 词：男性不育症 精子 抗体 精浆免疫抑制物 

分 类 号：R698.202[医药卫生—泌尿科学] R392.11[医药卫生—外科学]