丹参对家兔阿霉素性心肌病的保护作用——组织病理学及超微结构研究  

Protective Effects of RSM on Adriamycin-Induced Cardiomyopathy in Rabbits——A Light and Electron Microscopic Investigation

作　　者：白明东[1] 王扬宗[2] 

机构地区：[1]兰州军区总医院 [2]兰州医学院病理教研室

出　　处：《兰州医学院学报》1996年第4期6-9,共4页Journal of Lanzhou Medical College

摘　　要：实验用30只青紫兰家兔,随机分A组(注射阿霉素),B组(注射阿霉素和丹参)和C组(对照组),实验8周后处死动物,留取心肌标本作光镜及电镜观察。结果发现:心肌组织损伤主要位于乳头肌、肉柱及心内外膜下区域并集中于微血管周围;超微结构改变包括心肌细胞本身病变和间质毛细血管病变。同时发现B组光、电镜病变均比A组轻;B组家兔生存时间比A组明显延长。结果提示丹参对家兔阿霉素性心肌病有保护作用。30 Chinbhilla rabbits were used and randomly divided into three groups;Group A(10 rabbits) received adriamycin(ADR) only; Group B(10 rabbits)were given ADR and Radix Salviae Miltiorrhize (RSM); and Group C(10 rabbits) received normal Saline. The experiment lasted 8 weeks. Rabbits were sacrificed at the end of the experiment, those in agonal condition were also killed. The myocardial morphologic alterations were examined by light and electron microscopy. The results showed the myocardial lesions were mainly located in the papillary muscles, trabeculae carneae, subendocardial and subpericardial rigions and were frequently concentrated Perivascularlly; Ultrastructurally, the alterations of myocytes and intramyocardial capillaries were very conspicuous. The morphologic analysis showed the cardiac lesions were significantly milder in rabbits supplemented with RSM than those received ADR only(P<0. 01-0. 05);the survial time was prolonged in Group B. The results suggested that cardiomyopathy of ADR may be protected partially by RSM.

关 键 词：阿霉素性 心肌病 丹参 保护作用 组织病理学 

分 类 号：R285.5[医药卫生—中药学] R282.710.5[医药卫生—中医学]