利多卡因在全麻拔管中的应用  

Application of lidocaine in general anesthesia tracheal extubation

作　　者：王兵[1] 

机构地区：[1]成都市第二人民医院麻醉科,四川成都610017

出　　处：《西部医学》2006年第4期467-468,共2页Medical Journal of West China

摘　　要：目的探讨利多卡因气管内给药对全麻结束拔管时呛咳的抑制和对心血管反应的预防作用。方法选择择期手术全麻病人50例,随机分成A、B两组,每组各25例。拔管前10分钟,A组2%利多卡因1.5m g/kg直接由气管导管内给药,B组给予生理盐水5m l于气管导管内,观察气管拔管前5分钟呛咳的发生率和平均动脉压(M AP)、心率(HR)的变化。结果A组呛咳发生率8%(2/25),B组60%(15/25),A组拔管时的呛咳反应明显减少于B组(P<0.01)。A组拔管前5分钟M AP、HR与术前相比无显著性差异(P>0.05),对照组较术前明显升高(P<0.05)。结论利多卡因对减轻全麻结束时的呛咳和对心血管反应的预防有明显作用,值得临床应用。Objective To investigate the effects of intratracheal lidocaine administration on the prevention of side effects and cardiovascular response during tracheal extubation under general anesthesia. Methods Fifty ASA Ⅰ - Ⅱ grade patients were randomly divided into two groups with each being 25 patients ,aged 18-65 years. At 10 minute before tracheal extubation, Group A was given 2 % lidocaine intratracheally with the dose of 1.5 mg / kg. Group B was given 5 ml NS intratracheally. The incidence of bucking, and the variance of mean arterial pressure and heart rate at 5 minute before tracheal extubation were observed. Results The bucking incidence was 8 % （2/25）in Group A; whereas it was 60 ~A （15/25）in Group B, being significant difference between the two groups （P〈 0. 01）. In Group A, the average arterial pressure and heart rate did not show significant difference at 5 minute before tracheal extubation in comparison with preoperation （P〉0. 05）, but in Group B, they were obviously elevated at 5 minute before tracheal extubation in comparison with preoperation（P〈0. 05）. Conclusion Lidocaine is effective remedy in relieving bucking and preventing cardiovascular response during general anesthesia. It deserves clinical application.

关 键 词：利多卡因 全麻拔管 呛咳 

分 类 号：R614.2[医药卫生—麻醉学]