新型声学造影齐非损伤性估价正常心肌血流灌注的实验研究  

Noninvasive Assessment of Myocardial Perfusion in Normal Dogs with Intravenous injections of A New Contrast Agent

作　　者：谢峰[1] 勒斌[1] 李澎[1] 刘汉英[1] 杨浣宜[1] 

机构地区：[1]中国医学科学院,中国协和医科大学心血管病研究所,阜外心血管病医院

出　　处：《中国超声医学杂志》1996年第12期1-6,共6页Chinese Journal of Ultrasound in Medicine

基　　金：国家自然科学基金;美国李氏基金

摘　　要：本研究的目的是评定一种新型含有氟碳气体微泡的造影剂－ＦＸ４３０和ＦＸ５３０经静脉注射后能否产生心肌对比作用。在６条开胸犬分别注射经声振处理含有室内空气和氟碳气体的微泡造影剂。在每次注射后测量心肌视频密度峰值，并视觉观察心肌显影程度。静脉注射造影剂未产生血流动力学变化，未见有意义的副作用。每次静脉注射氟碳造影剂均可产生视觉可见的心肌显影，而空气微泡无一次注射产生心肌显影。定量分析显示，ＦＸ４３０和ＦＸ５３０产生较高的心肌视频密度（３９±１６比３±２，ｐ＜０．０００１）。结论：静脉注射ＦＸ４３０和ＦＸ５３０可产生恒定的心肌对比作用，且十分安全。The objective of this study was to determine whether a new contrast agent could produce myocardial contrast after intravenous injection of perflurocarbon microbubbles(FX430 and FX530).In 6 open-chest dogs,intravenous injections of dextrose albumin sonicated with either room air or perfluorocarbon were given under baseline conditions. Background-subtracted anterior myocardial peak videointensity was measured and visi ble myocardial opacification was assessed after each injection.The intravenous contrast medium the doses given produced no hemodynamic changes and no significant side effects. Visually evident myocardial contrast was obtained in all injections of the perfluorocarbon microbubbles but not in any injection of the room air microbubbles. FX430 and FX530 created much higher myocardial videointensity than room air microbubbles(39±16 vs 3±2,p<0.0001).Conclusion:Intravenous injections of FX430 and fx530 can safely produce consistent myocardial ultrasound contrast.

关 键 词：心肌灌注 超声心动图 微泡 造影剂 

分 类 号：R540.45[医药卫生—心血管疾病] R981.1[医药卫生—内科学]