医院感染败血症病原菌8年变迁及耐药性分析  

Pathogenic Bacteria and Drug Resistance in Nosocomial Septicemia:An 8-year Analysis of Their Changes

作　　者：周铁丽[1] 王赛芳[1] 李超[1] 刘庆中[1] 黄海霞[1] 

机构地区：[1]温州医学院附属第一医院,浙江温州325000

出　　处：《中华医院感染学杂志》2006年第7期825-827,共3页Chinese Journal of Nosocomiology

摘　　要：目的探讨医院感染败血症病原菌分布及耐药性变迁特点。方法血液培养采用全自动血培养仪,VITEK-AMS微生物鉴定仪进行病原菌鉴定和药敏试验。结果病原菌构成比中,革兰阳性菌呈上升趋势,其中以凝固酶阴性葡萄球菌构成比上升最为明显,但金黄色葡萄球菌构成比明显下降;革兰阴性菌和真菌构成比呈下降趋势;对革兰阳性菌和革兰阴性菌最敏感的药物分别为万古霉素和亚胺培南。结论医院感染败血症病原菌以革兰阴性菌为主,革兰阳性菌呈上升趋势,尤其是凝固酶阴性葡萄球菌成为医院感染败血症最主要的病原菌,病原菌对临床常用抗菌药物有较高的耐药性。OBJECTIVE To investigate the changes in pathogenic bacteria and drug resistance in nosocomial septicemia. METHODS The blood samples of inpatients were cultured with blood culture apparatus, VITEK-AMS were used to identify the pathogenic bacteria and conduct drug resistance test. RESULTS The proportion of Gram-positive cocci had been increasing, coagulase negative staphylococcus increased significantly, but the proportion of Staphylococcus aureus decreased significantly. The proportion of Gram-negative bacteria and fungi decreased too. Vancomycin and imipenem were the highest susceptible to Gram-positive and Gram-negative bacteria, respectively. CONCLUSIONS Gram-negative bacteria are the major pathogens in nosocomial septicemia. But Gram-positive cocci had been increasing in the past years. Coagulase negative staphylococcus is the main pathogen in nosocomial septicemia, pathogenic bacteria are higher resistant to the commonly used antibiotics.

关 键 词：医院感染 败血症 病原菌 耐药性 

分 类 号：R969.3[医药卫生—药理学]