12年来呼吸道感染病原菌回顾调查  

Pathogen Spectrum Distribution in Respiratory Tract Infection: A Retrospective Investigation During Past Twelve Years

作　　者：王水利[1] 罗小峰[1] 赵岚[1] 吴桦[1] 孙钢[1] 韩雪芳[1] 

机构地区：[1]陕西省人民医院,陕西西安710068

出　　处：《中华医院感染学杂志》2006年第7期828-830,共3页Chinese Journal of Nosocomiology

基　　金：罗氏感染研究青年医师基金资助(2001036)

摘　　要：目的调查12年呼吸道感染病原菌分布特点,为临床合理应用抗菌药物提供依据。方法采用回顾性统计调查分析。结果12年呼吸道感染共分离病原菌7 596株,G+球菌34.56%,G-杆菌48.62%,真菌占10.10%;前、后6年G+球菌25.96%和37.91%,金黄色葡萄球菌6.85%和10.28%、肺炎链球菌4.84%和6.68%、乙型溶血性链球菌4.26%和7.02%;G-杆菌63.33%和47.64%,铜绿假单胞菌8.46%和8.19%、大肠埃希菌7.97%和7.07%、肺炎克雷伯菌7.09%和5.21%;前、后6年真菌中以白色念珠菌为主,分别为6.06%和11.43%。结论12年来呼吸道感染病原菌分布发生显著变化,G+球菌构成比呈逐年上升,而G-杆菌构成比下降,真菌构成比显著上升。OBJECTIVE To investigate the pathogen spectrum distribution in respiratory tract infection during the past twelve years. METHODS The method was retrospectively analyzed. RESULTS A total of 7596 strains in clinical specimens were isolated. It showed that the isolating rate of Gram positive cocci, Gram negative bacilli and fungis was 34.56%, 48. 62% and 10.10%, respectively. The isolating rate of Gram positive cocci was 25.96% between Jan 1991 to Dec 1996, the most commonly isolated bacteria of which were Staphylococcus aureus, Streptococcuspneumoniae and β-hemolytic streptococci, with isolating rates being 6. 85%, 4. 84 % and 4.26%, respectively; the isolating rate of Gram negative bacilli was 63.33%, the most commonly isolated bacteria of which were Pseudomonas aeruginosa, Escherichia coli and Klebsiella pneumoniae, with isolating rates being 8.46%, 7.97% and 7.09%. The isolating rate of Gram positive cocci was 37.91% between Jan 1997 to Dec 2002, the most commonly isolated bacteria of which were S. aureus, ~hemolytic streptococci and Str. pneumoniae, with isolating rates being 10. 28%, 7.02% and 6.68%, respectively; the isolating rate of Gram negative bacilli was 47.64%, the most commonly isolated bacteria of which were P. aeruginosa, E. coli and K. pneumoniae, with isolating rates being 8.19%, 7.07% and 5.21%, respectively. The isolating rate of fungi was 6.06% and 11.43%, respectively during the two stages, the most commonly pathogen of which was Candida albicans. CONCLUSIONS The pathogen spectrum distribution in respiratory tract infection during the past twelve years has changed significantly. The isolating rate of Gram positive cocci and fungi, respectively is gradually increasing, but that of Gram negative bacilli is decreasing.

关 键 词：回顾性调查 呼吸道感染 病原菌分布 

分 类 号：R563.1[医药卫生—呼吸系统]