Enantioselective Pinacol Coupling of Aromatic Aldehydes Induced by Chiral Titanium Complexes  

作　　者：Qing Fang CHENG Xing You XU Ming Yan WANG Jun CHEW Wei Xing MA Xu Jie YANG 

机构地区：[1]Department of Chemical Technology, Huaihai Institute of Technology, Lianyungang 222005 [2]Materials Chemistry Laboratory, Nanjing University of Science and Technology, Nanjing 210094 [3]不详

出　　处：《Chinese Chemical Letters》2006年第7期887-890,共4页中国化学快报（英文版）

摘　　要：Asymmetric pinacol coupling of aromatic aldehydes with TiCl4-Zn in the presence of enantiopure squaric acid amidoalcohols afforded 1, 2-diols in excellent yields with high dl- diastereoselectivities and enantioselectivities in the range of 46-89% ee. Some factors influencing dl-diastereoselectivity and enantioselectivity were discussed.Asymmetric pinacol coupling of aromatic aldehydes with TiCl4-Zn in the presence of enantiopure squaric acid amidoalcohols afforded 1, 2-diols in excellent yields with high dl- diastereoselectivities and enantioselectivities in the range of 46-89% ee. Some factors influencing dl-diastereoselectivity and enantioselectivity were discussed.

关 键 词：Chiral squaric acid amidoalcohol PINACOL asymmetric coupling aromatic aldehyde. 

分 类 号：O625.41[理学—有机化学]