On-line Sweeping Sample Concentration in Micellar Electrokinetic Chromatography with Enhanced Sensitivity for the Deter-mination of Carbamazepine in Human Serum  

作　　者：Dan Dan HAN Chun WANG Zhi WANG Qiu Hua WU Xiao Huan ZANG 

机构地区：[1]College of Food Science and Technology,Agricultural University of Hebei, Baoding 071001 [2]Key Laboratory of Bioinorganic Chemistry, College of Science, Agricultural University of Hebei,Baoding 071001

出　　处：《Chinese Chemical Letters》2006年第7期953-956,共4页中国化学快报（英文版）

摘　　要：A sensitive and simple micellar electrokinetic chromatography （MEKC） method was developed for the determination of antiepileptic drug, carbamazepine （CBZ）, using sweeping on-line concentration method with photodiode array detection. Under the optimal conditions, the calibration curve was linear over a range of 0.5-40μg·mL^-1 for CBZ with a correlation coefficient of 0.998. The detection limit （S/N = 3：1） of CBZ was 0.10 μg·mL^-1. The sweeping-MEKC method has been successfully applied to the analysis of CBZ in human serum.A sensitive and simple micellar electrokinetic chromatography （MEKC） method was developed for the determination of antiepileptic drug, carbamazepine （CBZ）, using sweeping on-line concentration method with photodiode array detection. Under the optimal conditions, the calibration curve was linear over a range of 0.5-40μg·mL^-1 for CBZ with a correlation coefficient of 0.998. The detection limit （S/N = 3：1） of CBZ was 0.10 μg·mL^-1. The sweeping-MEKC method has been successfully applied to the analysis of CBZ in human serum.

关 键 词：On-line concentration carbarnazepine MEKC SWEEPING human serum. 

分 类 号：O626[理学—有机化学] O657.7[理学—化学]