血清脂质和脂质过氧化物及超氧化物歧化酶水平与冠状动脉病变的关系  

ASSOCIATION OF LEVELS OF SERUM LIPIDS,LIPOPEROXIDE AND SUPEROXIDE DISMUTASE WITH THE SEVERITY OF CORONARY STENOSIS

作　　者：但青宏[1] 黄元伟[1] 彭章平[1] 韩阳[1] 孙坚[1] 金争鸣[1] 

机构地区：[1]浙江医科大学附属第一医院心血管研究室,空军杭州疗养院工作

出　　处：《浙江医科大学学报》1996年第4期151-153,共3页

基　　金：国家自然科学基金

摘　　要：作者测定了５０例冠心病（ＣＡＤ）患者及６０例正常人的血清总胆固醇（ＴＣ）、甘油三酯（ＴＧ）、高密度脂蛋白胆固醇（ＨＤＬ－Ｃ）、载脂蛋白ＡＩ（ａｐｏＡＩ）、ａｐｏＢ，以及脂质过氧化物（ＬＰＯ）、红细胞超氧化物歧化酶（ＳＯＤ）的含量。结果表明，ＣＡＤ患者与正常人相比，ａｐｏＢ及ＬＰＯ水平明显增高（Ｐ均＜０．０１），ＨＤＬ－Ｃ及ａｐｏＡＩ水平明显降低（Ｐ均＜０．０１）；ａｐｏＡＩ、ａｐｏＢ、ＨＤＬ－Ｃ及ＬＰＯ的变化幅度随冠状动脉病变支数的增多而依次递增。ＨＤＬ－Ｃ为判断ＣＡＤ病变严重度的最佳参数。ＣＡＤ缺血性损伤的主要原因是脂质过氧化。Serum total cholesterol(TC), triglycerides(TG), high density lipoprotein cholesterol(HDL-C), apolipoprotein (apo)AI ,apoB, lipoperoxide(LPO)and superoxide dismutase(SOD)were measured in 50 patients with coronary artery disease(CAD)confirmed by coronary angiography and 60 healthy individuals. The results showed that in patients with CAD, apoB and LPO contents were significantly higher but HDL-C, apoAI contents greatly lower as compared with those of the healthy individuals; the decrease of serum HDL-C level had the most consistent association with the severity of CAD as assessed by angiography;Lipid peroxidation might be the major causes of ischemic damage in CAD.

关 键 词：冠心病 病因学 脂质过氧化物 超氧化物歧化酶 

分 类 号：R541.402[医药卫生—心血管疾病]