屏风固金颗粒抑菌抗炎作用的实验研究  

Study on the bacteriostasis and anti-inflammation activity of Pingfeng Gujin granules

作　　者：魏爱英[1] 王爱武[2] 张鉴[2] 耿晖[2] 宿莹莹[1] 

机构地区：[1]山东省立医院,山东济南250021 [2]山东省立医院天然药物研究中心,山东济南250021

出　　处：《中国医院药学杂志》2006年第7期834-836,共3页Chinese Journal of Hospital Pharmacy

摘　　要：目的:研究屏风固金颗粒抑菌抗炎作用。方法:采用体内体外相结合的方法观察屏风固金颗粒抑菌作用;通过小鼠腹腔毛细血管通透性实验、二甲苯致小鼠耳廓肿胀实验及大鼠蛋清性足趾肿胀实验测定其抗炎作用。结果:屏风固金颗粒在体外对常见的多种致病菌有不同程度的抑制作用,在体内对感染金黄色葡萄球菌和表皮葡萄球菌的小鼠有明显的保护作用;能明显抑制小鼠腹腔毛细血管通透性亢进、二甲苯致小鼠耳廓肿胀及蛋清性大鼠足肿胀。结论:屏风固金颗粒具有抑菌抗炎作用。ORJECTIVE To study the bacteriostasis and anti-inflammatory effects of Pingfeng Gujin granules（PFGJG）. METHODS The bacteriostasis of PFGJG was investigated in vivo and in vitro. Anti-inflammatory effects of PFGJG was observed by the celiac capillary permeability, ear edema induced by xylene in mice, and the foot edema induced by egg white in rats. RESULTS PFGJG had suppressive function in different degree on many common pathogenic in vitro and it also had significant protective effect against staphylococcus aureus and staphylococcus epidermidi in mice. PFGJG evidently inhibited the excessive celiac capillary permeability, ear edema induced by xylene in mice, and the foot edema induced by egg white in rats. CONCLUSION PFGJG has obvious bacteriostasis and anti-inflammatory effects.

关 键 词：屏风固金颗粒 抑菌作用 抗炎作用 

分 类 号：R285[医药卫生—中药学]