慢性阻塞性肺部疾病患者肺泡巨噬细胞内cAMP和cGMP变化  

Change of cAMP and cGMP in alveolar macrophages from chronic obstructive pulmonary diseases

作　　者：庞玉英[1] 张安成[1] 刘丽华[1] 魏道严[1] 左祥生[1] 赵江云[1] 宋卫东[1] 

机构地区：[1]安徽医科大学第一附属医院呼吸内科,安徽医科大学基础部,安徽中医学院

出　　处：《安徽医科大学学报》1996年第4期261-263,共3页Acta Universitatis Medicinalis Anhui

基　　金：国家自然科学基金;国家中医药管理局资助

摘　　要：检测７２例慢性阻塞性肺部疾病（ＣＯＰＤ）患者及２６例正常人血、支气管肺泡泡洗液（ＢＡＬＦ）和肺泡巨噬细胞（ＡＭ）内ＣＡＭＰ和ｃＧＭＰ。结果表明：（１）正常人与ｃＯＰＤ患者外周血ｃＡＭＰ及ｃＧＭＰ无明显差异。（２）慢性支气管炎患者支气管及肺泡灌洗液中ｃＡＭＰ／ｃＧＭＰ明显降低，（３）皮质激素较舒喘灵更能改善ｃｏＰＤ患者ＡＭ内ｃＡＭＰ／ｃＧＭＰ水平。The levels of cAMP and cGMP in serum,Bronchoalveolar Lavage Fluid(BALF)and Alveolar Macrophage(AM)from 72 patients with chronic obstruction pulmonary diseases(COPD)and 26 normal subjects were examined and results showed:(1)No significant differences were found between COPD and normal subjects on cAMP or cGMP levels in serum.(2)The level of cAMP/cGMP in Bronchi-Lavage(BL)and Alveolar-Lavage(AL)from chronic bronchitis were significantly lower.(3)Compared with Ventolin,cortisol improved the levels of cAMP/cGMP in AM from chronic bronchitis and asthma patients better.

关 键 词：阻塞性肺疾病 肺泡 巨噬细胞 cAMP CGMP 

分 类 号：R563.902[医药卫生—呼吸系统]