黄芪总甙对小鼠急性肝损伤的保护作用  

Protective effects of total glucosides of astragalus membranaceous Bge on liver injury in mice

作　　者：明亮[1] 张艳[1] 李卫平[1] 张红[1] 赵庆付 

机构地区：[1]安徽医科大学药理教研室,安徽医科大学病解教研室,巢湖市烔炀医院

出　　处：《安徽医科大学学报》1996年第4期267-269,共3页Acta Universitatis Medicinalis Anhui

摘　　要：采用化学药物引起急性肝损伤，观察黄芪总甙（ＴＧＡ）对小鼠肝脏的保护作用。实验结果表明，ＴＧＡ（４０、８０ｍｇ·ｋｇ－１·ｄ－１，ｉｇ×１０ｄ）可对抗四氯化碳（ＣＣｌ４，０．１％花生油溶液，１０ｍｌ·ｋｇ－１，ｉｐ）和醋氨酚（ＡＡｐ，２５０ｍｇ·ｋｇ－１，ｉｇ）引起的小鼠血清谷丙转氨酶、谷草转氨酶的升高，并对ＣＣｌ４和ＡＡＰ所致小鼠肝脏病理损伤有一定的保护作用。The protective effects of total glucosides of astragalus membranaceous Bge(TGA)on liver injury induced by carbon tetrachloride(CCl4) and acetaminophen(AAP)in mice were investigated.The results showed that TGA(40,80 mg·kg-1·d-1,ig×10 d) could significantly inhibit the elevation of ALT and AST in serum induced by CCl4 and AAP.It was also found that TGA could reduce the liver lesion by CCl4 and AAP.

关 键 词：黄芪 药理学 四氯化碳 醋氨酚 肝损伤 

分 类 号：R285.5[医药卫生—中药学] R575[医药卫生—中医学]