Clara细胞、Clara细胞分泌蛋白在哮喘发病机制中的作用  

Role of Clara Cell and Clara Cell Secretory Protein in the Pathogenesy of Asthma

作　　者：温志红[1] 农光民[2] 

机构地区：[1]广西壮族自治区人民医院儿科,南宁530021 [2]广西医科大学第一附属医院儿科,南宁530021

出　　处：《医学综述》2006年第13期769-770,共2页Medical Recapitulate

基　　金：广西科学基金项目(桂科青0447017)

摘　　要：Clara细胞是一种无纤毛上皮细胞,主要分布于终末细支气管和呼吸性细支气管上皮;Clara细胞具有活跃的增殖分化特性,参与支气管上皮损伤的修复过程。Clara细胞分泌蛋白(CCSP)是Clara细胞最主要的分泌产物,具有抗炎、抗纤维化的生物学特性。而支气管哮喘是一种慢性呼吸道炎症性疾病,本文就近年来Clara细胞、CCSP与哮喘发病机制关系的研究进展简要综述。Clara cells are epithelial cells without cilia located maily in the terminal bronchioles and the respiratory bronchioles. Clara ceils have the characters of proliferation and differentiation, participating in reparative process of bronchial epithelium injury . Clara cell secretory protein（CCSP） is the predominant product from Clara cells, which posses biological properties including anti-inflammation and anti-fibrosis. Bronchial asthma is a chronic inflammatory disorder. The brief review outlines the relationship between Clara cell, CCSP and the pathogenic mechanism of asthma recently.

关 键 词：哮喘 儿童 CLARA细胞 CLARA细胞分泌蛋白 

分 类 号：R725.6[医药卫生—儿科] R562.25[医药卫生—临床医学]