肾小管间质纤维化机制及防治进展  

The Mechanism of Renal Tubulointerstitial Fibrosis and the Progress in Prevention and Treatment

作　　者：赵爱青[1] 张晓明[2] 李荣山[1] 马存根[2] 

机构地区：[1]山西医科大学第二临床医学院肾内科,太原030001 [2]山西大同大学医学院内科教研室,山西大同037008

出　　处：《医学综述》2006年第13期773-775,共3页Medical Recapitulate

基　　金：山西省自然科学基金资助项目(20021120)

摘　　要：越来越多的证据表明肾间质细胞(包括肾间质成纤维细胞、肾小管上皮细胞等)、细胞因子在肾小管间质纤维化过程中起着重要的作用,并且相互作用共同推动着纤维化的进展。间质细胞增殖和凋亡失衡及细胞间质代谢失调也是造成肾小管间质纤维化的两个不可缺少的原因。进一步阐明肾小管间质纤维化的这些微观病理过程,对探讨临床防治措施有着重要的作用。There are increasing evidences that renal interstitial cells （including renal interstitial fibroblast, renal tubular epithelial cells, etc） and cytokines, play important roles in the progress of renal tubulointerstitial fibrosis, and they interact with each other and promote the progress of renal fibrosis together. The imbalance of interstitial cell proliferation and apoptesis and the metabolic disorder of intercellular substance, are two essential factors for renal tubulointerstitial fibresis. Further illuminate these micro pathological process is of great importance to clinical practice.

关 键 词：肾纤维化 肾小管上皮细胞 细胞因子 转分化 姜黄素 

分 类 号：R692.6[医药卫生—泌尿科学]