早产儿D-二聚体和纤溶酶原的动态变化研究  

Study on the dynamic changes of D-dimer and plasminogen in premature infants

作　　者：邝文英[1] 王豫黔[2] 朱小瑜[3] 汪伟山[1] 郑丽萍[1] 黄辉文[1] 

机构地区：[1]广东省珠海市妇幼保健院新生儿科,519001 [2]广东省遵义医学院第五附属医院 [3]广东省深圳市妇幼保健院儿科

出　　处：《中国新生儿科杂志》2006年第3期136-138,共3页Chinese Journal of Neonatology

基　　金：广东省珠海市科技计划项目;项目编号:PC200310071

摘　　要：目的观察不同日龄正常早产儿纤溶活性指标栓溶二聚体(D-二聚体,DD)和纤维蛋白溶酶原(纤溶酶原,PLG)生理水平及其变化规律。方法选取日龄1、5、10、20 d的早产儿各40 例及1、5、10,20 d正常足月儿各20例作对照,观察其纤溶指标DD、PLG值的日龄变化规律。结果早产儿和足月儿DD阳性在新生儿期较多见,尤其是在生后1周内,DD阳性率随日龄增长而减低,早产儿减低较慢。早产儿PLG在第1、5 d与足月儿比较差异无显著性(P>0．05),在第10、20 d与足月儿比较差异有显著性(32．00±11．82)％比(41．30±9．74)％,(27．58±9．04)％比(43．65 ±17．38)％,(P<0．05)。早产儿PLG随着日龄增长有下降趋势,而足月儿无明显变化。结论新生儿出生后DD阳性率高和较低活性PLG水平提示纤溶活性的增强,尤其是早产儿更明显。对新生儿特别是早产儿临床出现DD阳性或PLG降低时,对DIC诊断要慎重。Objective To survey the plasma levels of D-dimer （DD） and plasminogen （PLG） and their dynamic changes in different age of premature infants. Methods The plasma levels of DD and PLG were determined respectively in 40 premature infants and 20 full-term infants （control group） on the 1 st, 5th, 10th and 20th day of life. Results The positive DD was very common both in premature and full-term infants in neonatal period, especially in the first week of life. The positive rate of DD in premature infants decreased slowly by age in comparison with full-term infants. The plasma levels of PLG had no significantly difference between premature and full-term infants on the 1st, 5th day of life （P 〉 0. 05）, but the differences was significant on the 10th, 20th day of life, （32. 00 ± 11.82）% vs （41.30 ±9.74）%, （27.58 ±9.04）% vs （43.65±17.38）%, （P〈0.05）. The plasma levels of PLG in premature infants decreased by age, but no change in full-term infants. Conclusions Enhanced fibrinolysis is indicated by high DD and low PLG level in premature and full-term infants, particularly in premature infants. We can＇ t make diagnose of disseminated intravascular coagulation （ DIC ） with only positive DD and/or low PLG level in neonates, especially in premature infants.

关 键 词：婴儿 早产 D-二聚体 纤维蛋白溶酶原 

分 类 号：R722.6[医药卫生—儿科]