Betacellulin与胰岛β细胞再生  

Betacellulin and islet β cell regeneration

作　　者：李鸿[1] 罗敏[1] 

机构地区：[1]上海交通大学医学院附属瑞金医院上海市内分泌代谢病研究所,200025

出　　处：《国际内分泌代谢杂志》2006年第4期251-253,共3页International Journal of Endocrinology and Metabolism

摘　　要：Betacellulin(BTC)属表皮生长因子(EGF)家族,在胰腺中高表达,目前认为其可能通过erbB-1e、rbB-4受体或其特异受体促进胰岛细胞的增殖,诱导非胰岛β细胞向β细胞的分化,对糖尿病动物模型的研究显示高血糖可得到缓解。BTC单核苷酸多态性可能还与某些人群2型糖尿病的发生有关。BTC已成为近年来逐渐受到关注的与胰岛密切相关的因子。Betacellulin（BTC） is a member of the epidermal growth factor （EGF） family, which is high-expressed in pancreas. It is considered that the regenerative effect of BTC on islets/pancreas maybe through the following pathways： strengthening proliferation of islets, pancreas duct cells and/or promoting differentiation of ＂stem cells＂ in pancreas duct and islets（or cell from other sources）. The studies in diabetic animal models show hyper- glycemia is ameliorated. Some single nucleotide polymorphisms （SNP）s within BTC gene were also thought to be related with pathogenesis of type 2 diabetes mellitns in some ethnic groups. All data suggest that BTC maybe play an important role in regulating growth and differentiation of islets.

关 键 词：BETACELLULIN 胰岛 糖尿病 细胞再生 

分 类 号：R587.1[医药卫生—内分泌]