普萘洛尔和恬尔心对脂蛋白代谢的影响  

Effects of Propranolol and Diltiazem on Lipoprotein Metabolism

作　　者：王晓峰[1] 薛文青 

机构地区：[1]大连市解放军210医院,116021 [2]上海第二军医大学长海医院,200433

出　　处：《解放军医学高等专科学校学报》1996年第2期1-3,共3页Clinical Journal of Medical Officer

摘　　要：用体外培养人脐静脉内皮细胞单层(EC)观察普茶洛尔、恬尔心对脂蛋白代谢的影响.将等量的高脂蛋白血清分别与两药混合后加于内皮细胞单层培养基上孵化10h,取培养上清液检测甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、极低密度脂蛋白(VLDL).结果显示:普茶洛尔显著降低LDL水平(P<0.01),对脂蛋白代谢产生有益影响.恬尔心显著降低TG水平(P<0.05),同时亦降低HDL水平(P<0.01),其对脂蛋白代谢的作用尚难评估.The effects of diltiazem and propranolol lipoprotein metabolism were studied in culture vein endotheliocyte monolayers. We found that propranolol can significantly decrease low-density lipoprotein(LDL)level of the culture medium (P<0.01),diltiazem can decrease triglyceride (TG) level(P<0.05)and high-density lipoproteins (HDD level (P<0.01)of the culture medium. The results suggest that propranolol is beneficial to hyperlipoproteinemia. The effects of diltiazem on hyperlipoproteinemia are difficult to assess.

关 键 词：普萘洛尔 恬尔心 脂蛋白 代谢 药理学 

分 类 号：R972.6[医药卫生—药品]