度冷丁滥用者尿中原体及其代谢产物的分析研究  

Studies on the Analysis of Meperidine and its Main Metabolites in urine of Meperidine Addicts

作　　者：沈敏 薛月华[1] 沈保华 向平 刘伟 

机构地区：[1]司法部司法鉴定科学技术研究所,上海市第一人民医院护士学校

出　　处：《法医学杂志》1996年第2期81-83,76,共4页Journal of Forensic Medicine

摘　　要：本研究利用ＧＣ／ＭＳ（ＥＩ．ＰＣＩ）技术，在度冷丁滥用者尿中确认了６种代谢产物。并建立了ＧＣ／ＦＩＤ分析度冷丁及其代谢产物的方法。方法线性范围为０．１～２０μｇ／ｍｌ，变异系数小于１０％，最小检出量为５０ｎｇ／ｍｌ，适用于度冷丁成瘾者尿中含量的测定。Six meperidine metabolites are identified by GC/MS(EI, PCI) in the urine of meperidine addicts.A GC/FID procedure for determination of meperidine and its main metabolites in human urine is also developed. Calibration curve is lineat over the rang 0. 1-20ug/ml, me results reproducible (cv<10%), the sensitivity limit is about 50ng/ml.The method is shown to be applicable to measuring urine concentra-tion of meperidine addicts.

关 键 词：药物滥用 度冷丁 代谢产物 尿 气相色谱法 

分 类 号：R595.504[医药卫生—内科学] R971.1[医药卫生—临床医学]