正交实验考察荜茇提取物-β-环糊精包合物包合工艺  

Orthogonal test for optimizing technique of piper extract-β-cyclodextrin inclusion complex

作　　者：李萍[1] 陈善[2] 丁建新[1] 窦媛媛[1] 王海燕 王洪权[1] 

机构地区：[1]军事医学科学院微生物流行病研究所,北京100071 [2]总后卫生部药品仪器检验所,北京100071 [3]北京宝泰宁堂生物技术有限公司,北京100176

出　　处：《军事医学科学院院刊》2006年第3期236-239,242,共5页Bulletin of the Academy of Military Medical Sciences

摘　　要：目的:用饱和水溶液法制备荜茇提取物-β-环糊精包合物。方法:采用正交实验设计,以包合率和产率为指标筛选最佳包合工艺。结果:最佳包合工艺为A3B1C3D1,即β-环糊精与提取物的比例为8∶1(g/g),包合温度为30℃,包合时间为6 h,β-环糊精与水的比例为1∶22(g/m l)。此条件下的包合率和产率分别可达约79%和75%。结论:通过正交实验优化出的荜茇提取物-β-环糊精包合物包合工艺能达到较高的包合率和产率。Objective：To prepare piper extract-β-cyclodextrin inclusion complexes by coprecipitation, Method：An orthogonal test was designed to optimize the technique of inclusion complexation by ratio of inclusion complexation and ratio of productivity. Results：The optimal technique of inclusion complexation was A3B1C3 D1, i.e. the ratio of β-cyclodextrin to extract of piper was 8：1 （g/g）, the temperature was 30℃ ,the time was 6 hours and the rates of β-cyclodextrin to the volume of water was 1 ： 22 （g/ml）. With the optimal technique the ratio of inclusion complexation and productivity were about 79% and 75% ,respectively. Conclusion： High ratio of inclusion complexation and productivity are gained by orthogonal test.

关 键 词：荜茇 包合物 饱和水溶液法 正交实验 

分 类 号：TQ460.1[化学工程—制药化工]