中国不同区域婴儿抗百日咳 白喉 破伤风母体抗体水平的调查  

Investigation on Antibodies of DTP in Infants Between the Different Regions in China

作　　者：侯启明[1] 马霄[1] 田博[2] 刘德铮[2] 肖詹荣[2] 杨晓明[3] 陈平纡[4] 项美娟[3] 付惠兰 吴玫[6] 王梨苹[7] 梁雅文[1] 张路民[1] 张庶民[1] 

机构地区：[1]中国药品生物制品检定所,北京100050 [2]北京生物制品研究所,北京100024 [3]武汉生物制品研究所,湖北武汉430046 [4]兰州生物制品研究所,甘肃兰州730046 [5]成都生物制品研究所,四川成都610063 [6]长春生物制品研究所,吉林长春130062 [7]上海生物制品研究所,上海200052

出　　处：《中国计划免疫》2006年第3期209-211,共3页Chinese Journal of Vaccines and Immunization

摘　　要：目的调查中国不同区域婴儿抗百日咳、白喉、破伤风母体抗体水平。方法在10年内分别在中国6个不同区域,对3月龄左右未接种过百白破联合疫苗(DPT)的健康婴儿体内抗百日咳、白喉、破伤风抗体水平进行了8次调查。分别检测了抗百日咳凝集原(Aggs)抗体1 602人,抗百日咳毒素(PT)和抗丝状血凝素(FHA)抗体790余人,白喉、破伤风抗体1 196人。结果未接种过DPT健康婴儿体内的抗百日咳Aggs抗体和抗PT、FHA抗体都分别<1∶320和<20EU/ml的保护水平;抗白喉、抗破伤风抗体水平都<0.01HAU/ml的保护水平,而且在婴儿群体中这种低抗体水平不随时间、不依城市或农村、发达地区或不发达地区而变化。结论DPT的初免月龄建议提前至2月龄,推广使用无细胞DPT,在低龄婴儿达到有效预防百日咳、白喉、破伤风的目的。Objective In order to investigate the antibodies of DTP in infants who have no inoculated DTP vaccine. Method We have performed eight studies around the six regions of China between 1992-2001. Eight investigations on the anti-pertussis diphtheria tetanus antibody levels of about 3 month-old healthy infants without injection of pertussis diphtheria tetanus was made. 1 602 were detected anti-pertussis agglutinating antigens antibody （AGGs）, over 790 were detected anti-AGGs antibody （FHA）, and anti-pertussis toxicity （PT）antibody, and filamentous hemagglutinin, and 1 195 were detected diphtheria and tetanus antibody. Results The result shows that the antibody titers of anti-pertussis are less than 1 ： 320 and 20EU/mL. Antibody titers of anti-diphtheria and anti-tetanus are less than 0.01HAU/mL respectively. Three kinds of antibodies are more less than protective level, and there are no any changes between the different time and regions.

关 键 词：百白破联合疫苗 婴儿 抗体 

分 类 号：R166[医药卫生—公共卫生与预防医学]