酒精性心肌病:病理生理,临床与药理学  

Alcoholic Cardiomyopathy:Pathology,Physiology,Clinical and Pharmacology

作　　者：曹斯琦[1] 陈丁丁[1] 

机构地区：[1]中国药科大学药学院药理研究室,南京210009

出　　处：《海峡药学》2006年第3期4-8,共5页Strait Pharmaceutical Journal

摘　　要：酒精性心肌病(ACM)是一种长期大量饮酒引起的扩张性心脏病。本文总结近年文献,概括介绍了酒精性心肌病,着重叙述了ACM心肌细胞死亡,过氧化损伤,心肌微细结构及其功能,蛋白合成与心肌重构,炎症,信号传导,神经体液系统等因素的生理病理构制,对现行ACM治疗药物的药理学研究进展进行讨论。Alcoholic Cardiomyopathy （ACM）is a dilated cardiomyopathy cause by chronic,great of alcohol consumption. In this review,we summarize many recent research articles to introduce ACM in general,highilight the physiological and pathological mechanism including cell death,over-oxidation injury,the stucture and function of intracellular organelle, protein synthesis and myocardial remodeling inflammation, signal transduction neurohormonal systems. Meanwhile,we discuss the pharmacology of drugs currently used.

关 键 词：酒精 酒精性心肌病 信号传导 

分 类 号：R927.4[医药卫生—药学]