79例卵母细胞浆内单精子注射术(ICSI)治疗男性不育临床及安全性研究  

Study of the security in ICSl with 79 cases which were performed to cure male sterility.

作　　者：汤丽莎[1] 冯玉华[1] 李延林[1] 罗建[1] 马雪花[1] 吴凤[1] 许娟[1] 

机构地区：[1]江苏省连云港市妇幼保健院,222001

出　　处：《中国优生与遗传杂志》2006年第7期108-109,共2页Chinese Journal of Birth Health & Heredity

摘　　要：目的对比分析应用卵母细胞浆内单精子注射(ICSI)技术和常规的体外受精与胚胎移植(IVF-ET)技术治疗不育的临床资料,为卵母细胞浆内单精子注射技术的临床应用提供安全性依据。方法回顾性分析79例接受技术治疗不育的资料,并与同期288例接受常规的体外受精与胚胎移植(IVF-ET)技术的病例对比分析。结果在受精率及流产率方面,ICSI组均低于IVF-ET组,卵裂率、妊娠率及胚胎形态方面,围生期结果两组比较无显著性差异(P>0.05)。结论ICSI治疗男性严重少弱精子症的效果是肯定的,出生后代安全性与IVF-ET相似。但ICSI出生后代安全性的确定仍需大样本研究及长期随访。Objective： To compare and analyse the clinical data of intracytoplasmic sperm injection （ICSI） and in-vitro fertilization （IVF）, and offer the security foundation for application in ICSI. Methods： The data of 79 cases of ICSI and 288 cases of IVF were analysed retrospectively, Results： The fertilization rate and the abortion rate of ICSI was significantly lower than that of IVF, there were no significant differences in early embryonic development, pregnancy outcome and perinatal outcome between IVF and ICSI. Conclusion ： The security of descendant in ICSI was similar to that in IVF, but the study of larger specimens and a consistant follow-up is still essential.

关 键 词：受精 体外 胞浆内 单精子注射 妊娠结局 

分 类 号：R698.2[医药卫生—泌尿科学]