益心降压胶囊对原发性高血压左室肥厚患者左室重量指数及血浆神经肽Y的影响  

EFFECT OF YIXINJIANGYA CAPSULE ON LEFT VENTRICULAR MASS INDEX AND PLASMA NEUROPEPTIDE Y IN PATIENTS WITH LEFT VENTRICULAR HYPERTROPHY OF ESSENTIAL HYPERTENSION

作　　者：段学忠[1] 孙西庆[1] 蔡新吉[1] 

机构地区：[1]济南军区总医院,济南250031

出　　处：《中国中医药科技》2006年第4期213-214,共2页Chinese Journal of Traditional Medical Science and Technology

摘　　要：目的:观察益心降压胶囊对阴虚阳亢血瘀证型Ⅱ期原发性高血压左室肥厚(LVH)患者左室重量指数(LVMI)及血浆神经肽Y(NPY)含量的影响。方法:将93例患者随机分为治疗组(62例)和对照组(31例),两组均口服依那普利,治疗组加服益心降压胶囊。两组疗程均为24周。采用超声心动图仪和放射免疫分析法分别测定两组患者治疗前后LVMI和血浆NPY含量。另选30例健康人测定上述指标作对照。结果:治疗前两组患者LVMI和血浆NPY含量均较健康组显著升高(P<0.01);治疗后两组患者LVMI和血浆NPY含量均显著降低(P<0.05或P<0.01);且治疗组优于对照组(P<0.05或P<0.01);治疗组与健康组比较,无显著性差异(P>0.05)。两组血压下降幅度比较无显著性差异(P>0.05)。结论:阴虚阳亢血瘀证型Ⅱ期原发性高血压LVH患者LVMI和血浆NPY含量显著高于健康人;益心降压胶囊具有较好的逆转LVH和降低血浆NPY含量的作用,推测其逆转LVH的机制与降低NPY有关。Objective: To observe the effect of yixinjiangya capsule on left ventricular mass index(LVMI) and plasma neuropeptide Y(NPY) in patients with left ventricular hypertrophy(LVH) of essential hypertension at stage Ⅱ.Methods: 93 patients were randomly divided into treated group and control,the two groups both treated with enalapril,simultaneously the treated group were given yixinjiangya capsule.The treatment time was 24 weeks.Duplex sonography and adioimmunoassay were respectively used to examine LVMI and the level of plasma NPY before and after treated in the two groups,meanwhile 10 healthy persons were taken as control.Results:Before treated,LVMI and plasma NPY level were significantly higher in both treated groups than that in the healthy,which lowered significantly after treated,especially changes in the group with yixinjiangya capsule were more obvious than those in the western medicine group.Blood pressure was significantly lowered in both treated groups,there was no difference between them.Conclusion: Yixinjiangya capsule had good effect in improving LVH and lowering plasma NPY.It is presumed that lowering NPY level maybe one of its mechanism of improving LVH.

关 键 词：原发性高血压/中医药疗法 肥大 左心室/中医药疗法 @益心降压胶囊/治疗应用 神经肽Y/血液 人类 

分 类 号：R259[医药卫生—中西医结合]