氧化铝-羟基磷灰石修复兔骨腔隙性骨缺损的CT观察  

The effects in repair of lacunars defects with Al_2O_3-HA artificial bone in rabbit bone

作　　者：徐武清[1] 赵燚[1] 赵喆[2] 马英锋[1] 王虹[1] 赵自强[1] 

机构地区：[1]宁夏医学院,宁夏银川750004 [2]瑞典斯德哥尔摩大学

出　　处：《宁夏医学杂志》2006年第7期486-488,F0002,共4页Ningxia Medical Journal

基　　金：宁夏自然科学基金资助(编号E006-2004);宁夏国际合作项目资助(编号05GJ-11400)

摘　　要：目的通过CT摄片观察致密型氧化铝-羟基磷灰石人工骨材料修复兔骨腔隙性骨缺损的效果。方法采用放电等离子烧结(SPS,SparkPlasmaSintering)技术制备氧化铝-羟基磷灰石(Al2O3-HA)人工骨,植入兔股骨腔隙性骨缺损模型中,术后1天、12周通过CT摄片,观察人工骨与兔骨结合状况。结果术后12周宿主骨缺损完全愈合。结论SPS技术烧结的氧化铝-羟基磷灰石人工骨具有良好的生物相容性,是一种理想的承重骨人工骨替代材料。Objective To investigate the performance of dense in the repair of lacnars defects in rabbit thighbone. Methods Fully dense Al2O3 - HA artificial bone composite materials were lust prepared by Spark Plasma Sintering technique and then implanted into the lacunars defects in rabbit thighbone model. CT was applied at time interval after operation of 1 day and 12 weeks respectively to observe the integration condition between the artificial bone and rabbit bone. Results New, bone callus can be found after 4 weeks and the defects were healed totally after 12 weeks. Conclusion The fully dense Al2O3 - HA composites artificial bone materials have excellent biocompatibility and are very promising for implant application as artificial substitutes of mess- load bone tissues.

关 键 词：组织工程 人工骨 氧化铝羟基磷灰石 

分 类 号：R318.08[医药卫生—生物医学工程] R687[医药卫生—基础医学]