盐酸地尔硫药物树脂的体外释药动力学  

Release kinetics of diltiazem hydrochloride resinate in vitro

作　　者：孙长山[1] 刘宏飞[1] 潘卫三[1] 张立婷[2] 贾宁 

机构地区：[1]沈阳药科大学药学院,辽宁沈阳110016 [2]沈阳富东制药有限公司,辽宁沈阳110041 [3]沈阳天灵制药有限公司,辽宁沈阳110141

出　　处：《沈阳药科大学学报》2006年第7期417-420,447,共5页Journal of Shenyang Pharmaceutical University

摘　　要：目的制备盐酸地尔硫药物树脂复合物并对其体外释药动力学进行考察。方法以静态交换法制备了盐酸地尔硫药物树脂复合物并对盐酸地尔硫药物树脂在不同释放介质(去离子水、0.15 mol.L-1NaCl1、mol.L-1NaCl、0.15 mol.L-1HCl、0.15 mol.L-1KCl溶液)中的释药动力学进行了考察。结果体外释药动力学研究表明,盐酸地尔硫药物树脂的释药速率随着释放介质中离子强度的增大、温度的升高而加快、且释药速率与反离子种类有关。结论盐酸地尔硫药物树脂的释药速率与释放介质的离子强度、反离子种类、介质温度有关。Objective To prepare the diltiazem hydrochloride resinates and study the release kinetics of the drug-resinate in vitro. Methods The drug-resinates were prepared by bath method. The drug release kine-tics were investigated in different releasing mediums （deionic water, 0.15 mol·L^-1 NaC1,NaCI, 1 mol· L^- 1 NaCI, 0.15 mol·L^- 1 HCI and 0.15 mol· L^- 1 KCI）. Results It was shown that the release rate increased with the increase of ionic strength of the release mediums and temperature. The release rate changed with the counter-ion type. Conclusions The release rate of the drug-resinates is correlated with ionic strength of the release mediums, the type of counter-ion and temperature.

关 键 词：盐酸地尔硫革 离子交换树脂 离子交换反应 释药动力学 

分 类 号：R94[医药卫生—药剂学]