心力衰竭患者自然杀伤细胞活性的变化  

Change of NK cells activity in patients with congestive heart failure

作　　者：姚恒臣[1] 李复领[1] 赵宗进[1] 胡立萍[1] 陈双峰[1] 刘燕[1] 

机构地区：[1]聊城市人民医院心内科,山东聊城252000

出　　处：《中国急救医学》2006年第7期491-493,共3页Chinese Journal of Critical Care Medicine

基　　金：山东省科技发展计划项目(No.991205914)

摘　　要：目的探讨充血性心力衰竭（CI-IF）患者自然杀伤（NK）细胞活性的变化。方法选择NYHAⅡ-Ⅳ级的CI-IF患者48例作为观察组，30例健康查体者作为对照组。应用流式细胞仪测定全血NK细胞数目，应用改良MIT法测定NK细胞杀伤活性。结果CHF患者循环NK细胞和NK细胞杀伤活性显著降低，并与心力衰竭程度呈负相关（r=-0．873、-0．949，P均＜0．001）。结论CHF患者NK细胞数目和NK细胞活性显著降低，可能是CHF患者免疫功能异常的机制之一。Objective To explore the changes of activity of natural killer cells in patients with congestive ＂heart fail ure（CHF）. Methods 30 normal controls and 48 patients with CHF were recruited according to NYHA standard. NK cells were determined by flow cytometry. NK cells killing activity were examined with modified MTF approach. Results Compared with normal control group, circulating NK cells and NK cells activity from patients with CHF decreased significantly, and negtively corraleted with the degree of heart failure（ r = - 0.873, - 0. 949; Pall〈 0.001 ）. Conclusions It decreasion of NK cells number and NK cells killing activity in patients with CHF, may be one of the mechanism of dysfunction of immune system in patients with CHF.

关 键 词：充血性心力衰竭 自然杀伤细胞 流式细胞仪 

分 类 号：R541.61[医药卫生—心血管疾病]