(PPh_3)_2PdCl_2/CuI催化合成4-硝基苯乙炔  

Synthesis of 4-Nitrophenylacetylene Catalyzed by(PPh_3)_2PdCl_2/CuI

作　　者：丁丽琴[1] 王维[1] 张爱清[1] 

机构地区：[1]中南民族大学化学与材料科学学院催化材料科学湖北省重点实验室,武汉430074

出　　处：《中南民族大学学报（自然科学版）》2006年第2期8-11,共4页Journal of South-Central University for Nationalities：Natural Science Edition

基　　金：国家自然科学基金资助项目(50373052);湖北省自然科学基金重点资助项目(2001ABA009)

摘　　要：为寻求更为实用的硝基苯乙炔的制备方法,在(PPh3)2PdC l2/Cu I催化下,由4-溴硝基苯和2-甲基-3-丁炔-2-醇反应生成2-甲基-4-(4-硝基苯)-3-丁炔-2-醇,再经N aOH的甲苯溶液回流得到4-硝基苯乙炔.催化剂用量仅为4-溴硝基苯的0.05%(以摩尔计),总收率为87%。产物经元素分析、红外光谱和核磁共振等表征.In order to seek more practical method, 4-nitrophenylacetylene was synthesized via the reaction 4- bromonitrobenzene with 2-methyl-3-butyn-2-ol in the presence of bis （triphenylphosphine）palladium chloride and cuprous iodide, followed by refluxing with sodium hydroxide in toluene. The quantitative of catalyst was only 0. 05 percent of 4-nitrophenylacetylene （counted in mole）, with an overall yield of 87%. The product was Characterized by element analysis and the spectra data of IR and 1H NMR.

关 键 词：二(三苯基膦)二氯化钯/碘化亚铜 4-硝基苯乙炔 催化 合成 

分 类 号：TQ225.241[化学工程—有机化工] TQ246.35