实验性牙齿移动中TG内P2X3受体的表达变化  

Change of P2X3 receptor expression in rat trigeminal ganglion during experimental tooth movement

作　　者：曹阳[1] 赖文莉[2] 陈扬熙[2] 

机构地区：[1]中山大学光华口腔医学院正畸科,广东广州510055 [2]四川大学华西口腔医学院正畸科,四川成都610041

出　　处：《第四军医大学学报》2006年第13期1156-1159,共4页Journal of the Fourth Military Medical University

基　　金：国家自然科学基金(30471912)

摘　　要：目的:研究正畸牙移动中加力后P2X3受体在三叉神经节的表达变化规律,以探讨P2X3受体在正畸牙移动疼痛机制中的作用.方法:以雄性SD大鼠为实验对象,模拟临床矫治的牙移动过程,应用免疫组织化学手段进行研究.结果:大鼠牙齿加力后,观察到三叉神经节神经元P2X3受体免疫反应阳性率增高,并呈现一定的时间规律:实验后1 d开始出现变化,实验后3 d达高峰,14 d后下降至与对照组基本一致.结论:大鼠牙移动过程中,三叉神经节内(TG)的P2X3受体表达变化是一过性变化,呈现短时上调的规律,时间与正畸牙移动疼痛时间一致.AIM： To investigate the change of P2X3 receptor expression in the trigeminal ganglion sensory neurons after the nociceptive stimulation by orthodontic tooth movement force. METHODS： Male Sprague-Dawley rats underwent the mimic orthodontic tooth movement. Immunohistochemistry and immunofluorescence were applied in studying the change of P2X3 receptor expression during experimental tooth movement. RESULTS： The proportion of P2X3 receptor-positive sensory neurons increased after giving force to the teeth of rats, to the peak 3 d later and returned to control values at 14 d. CONCLUSION： The P2X3 receptor expression is transiently upregulated and anterogradely transported in trigeminal primary sensory neurons in the process of orthodontic tooth movement. P2X3 receptor may play a role in the pathomechanism of nociceptive responses in primary sensory neurons during orthodontic clinic treatment.

关 键 词：正畸牙移动 三叉神经节 ATP P2X3受体 

分 类 号：R651.15[医药卫生—外科学]