大黄素对大鼠癫痫模型的脑保护作用  

The protective effect of emodin on brain of epileptic rat model

作　　者：顾建文[1] 郑崇勋[1] 杨文涛[2] 李翠莹[2] 邢学民[2] 杨立斌[2] 夏勋[2] 马原[2] 

机构地区：[1]西安交通大学生命科学院生物医学工程系 [2]成都军区总医院神经外科,成都610083

出　　处：《中华神经医学杂志》2006年第7期676-680,共5页Chinese Journal of Neuromedicine

摘　　要：目的观察大黄素对癫痫大鼠的脑保护作用。方法120只大鼠分为对照组(n=24)、模型组(n=24)和给药组(n=72)。观察大黄素对大鼠脑含水量、脑皮层超氧化物歧化酶(SOD)活性、丙二醛(MDA)水平和脑皮层Na^+-K^+ATP酶的影响,并且比较三组大鼠的脑组织病理切片与电镜照片,观察其形态变化。结果大黄素可减轻脑水肿,升高SOD、Na^+-K^+ATP酶活性,降低MDA水平,影响多个病理生理通路,具有脑保护作用。结论大黄素可能是大黄发挥脑保护作用的有效成分之一,为临床治疗癫痫提供了一条新的途径。Objective To observe the protective effect of emodin on the epileptic rat model. Methods After 120 rats were randomized into 3 groups： control group （n=24）, model group （n=24） and emodin-treated group （n=72）, we observed the effect of emodin on brain water content, rat cerebral cortex SOD activity, MDA level and cortex Na^＋-K^＋ ATP enzyme in each group, followed by studing the pathological sections and electron microscopic features of three groups. Results Emodin alleviated brain edema, raised SOD, enhanced Na^＋-K^＋ ATP enzyme activity, reduced MDA level, and so influenced the physio-pathological passages, thus exerting protective action on brain, conclusion Emodin containing composition of rhubarb is effective in protecting brain, which gives a new way to the treatment of epilepsy.

关 键 词：大黄 大黄素 癫痫 脑保护 

分 类 号：R285.5[医药卫生—中药学]