天晴复欣治疗儿童乙型肝炎病毒感染疗效观察  

Efficacy of hepatitis B virus infection treated with tianqingfuxin in children

作　　者：邹愚[1] 李传贵[2] 吴世韬[1] 

机构地区：[1]泸州医学院附属医院,四川泸州646000 [2]威远县人民医院,四川威远642450

出　　处：《现代医药卫生》2006年第15期2269-2271,共3页Journal of Modern Medicine & Health

摘　　要：目的:观察天晴复欣对儿童乙肝病毒感染的疗效。方法:比较天晴复欣与干扰素对8～14岁儿童乙肝病毒感染的疗效,并探索治疗早期HBVDNA定量变化与疗效的关系。结果:天晴复欣治疗4个月时综合疗效完全应答率(ALT复常,HBVDNA及HBeAg阴转)为22.5%,部分应答率为37.5%,血清中HBVDNA定量由(52.4±38.6)×105cop/ml降为(8.8±7.9)×105cop/ml,与治疗前比较有显著差异P<0.01;6个月随访时完全应答率为25.0%,部分应答率37.5%,HBVDNA定量降为(6.9±6.1)×105cop/ml,与治疗前比较差异有显著性P<0.01。与干扰素治疗相比,无显著差异性(P>0.05):干扰素组治疗4个月时完全应答率为20.0%;部分应答率为40.0%;HBVD-NA定量由(51.7±36.8)×105cop/ml降为(10.1±9.8)×105cop/ml,P<0.01,疗效相当;6个月随访时干扰素组完全应答率25.0%;部分应答率35.0%;HBVDNA定量降为(7.8±6.9×10)×105cop/ml,与治疗前比有显著差异P<0.01。天晴复欣治疗2个月时HBVDNA下降>2个对数级者疗程结束时综合疗效完全应答和部分应答率与治疗4个月时差异无显著性,P>0.05。不良反应小。结论:天晴复欣对儿童乙肝病毒感染与干扰素有相似效果,治疗安全,是治疗儿童乙肝病毒感染的有效方法。治疗2个月时HBVDNA下降>2个对数级者抗病毒效果显著,可作为天晴复欣继续治疗至结束的标准之一;<2个对数级者可停药,以减少药物和费用的浪费。Objective：To evaluate the efficacy of tianpingfuxin on the children with hepatitis B.Methods：The efficacy of tianqingfuxin or interferon-or on the 8 to 14 years on old children with hepatitis B was observed at the end of 4 and 6 months.The relation between early stage change of HBVDNA quantitation and therapeutic effect was explored.Results.The full response rate to the treatment at the end of combining therapy （ALT reply,negative convertion of HBVDNA and HBeAg） is 22.5%;Tianqingfuxin lowered HBV DNA quantitation from （52.4±38.6）×los cop/ml to （8.8±7.9）×10^5cop/ml,and the partial response rate of the treatment at end of therapy is 37.5%,While that of interferon ct is 20.0%,from （51.7±36.8）×10^5 cop/ml to （10.1±9.8）×10^5 cop/ml,40.0% respectively;There is no significant difference between two groups （P〈0.01）.The response rate at the end of the sixth month is 25.0%;Tianqingfuxin lowered HBV DNAquantitation to （6.9±6.1）×10^5 cop/ml,and the partial response rate of the end of the sixth months is 37.5%,while that of interferon-or is 25.0%,（7.8±6.9× 10） ×10^5 cop/ml,35.0% respectively.at the end of the second month,the patients of Logarithm class reduced by 2 through treatment with tianqingfuxin is up to 87.5% and 55.6% of the full responsers and the part sesponsers,respeetively.Tbe side effect of tianpqingfuxin is less than that of interferonor.Conclusion：The efficacy of the tianqingfuxin is similar with that of interferonr;The anti-virus therapy of tianqingfuxin on the children with pepatitis B is efficent,safe and economin.This therapy shotdd be an alternative way of anti-virus therapy on the children with hepatitis B.

关 键 词：天晴复欣 儿童 乙肝病毒 疗效 观察 

分 类 号：R271[医药卫生—中医妇科学]