机械瓣膜置换术后低强度抗凝治疗的临床研究  

Clinical analysis of anticoagulant therapy with low intensity after mechanical heart valve replacement

作　　者：章晔[1] 唐燕华[2] 

机构地区：[1]江西省人民医院心胸外科,南昌330006 [2]南昌大学第二附属医院心胸外科,南昌330006

出　　处：《江西医药》2006年第6期348-350,共3页Jiangxi Medical Journal

摘　　要：目的探讨低标准口服抗凝药物治疗在国人接受心脏人工机械瓣膜置换术后的临床可行性及意义。方法随访140例心脏人工机械瓣置换术后患者低强度抗凝药物治疗条件下的近远期临床结果,分析各种抗凝相关并发症的发生率。结果由于机械瓣膜的材料和工艺的不断改进,华法令抗凝强度有所下降,以INR值1.5～3.0为标准,证明低强度抗凝是可行的。结论由于国人的生理及药代动力学特点,低强度抗凝药物治疗具有可靠的临床实用性。Objective To investigate the feasibility and significance of antieoagulation therapy with low intensity in patients after mechanical heart valve replacement in China. Methods 140 patients with low intensity of oral anticoagulant therapy after mechanical heart valve replacement were followed. They were evaluated for the clinical effect and the rate of antieoagulation complications. Results With the improvement of the valve material and machining process, the antieoagulation therapy with low intensity,INR 1.5-3.0, was feasible. Conclusion The antieoagulation therapy with low intensity for Chinese people is clinical significance.

关 键 词：心脏瓣膜疾病 华法令 抗凝治疗 

分 类 号：R654.2[医药卫生—外科学]