麻黄、白芍复方中药改善急性加重期慢性阻塞性肺疾病患者肺功能和血清细胞因子的水平  

Effect of compound ephedra and white peony decoction on pulmonary function and serum cytokine level in patients with chronic obstructive pulmonary diseases at acute exacerbation phase

作　　者：张霞[1] 王玲[2] 刘春红[2] 薛玉文[2] 李玉[2] 

机构地区：[1]解放军国防大学医院呼吸科,北京市100091 [2]山东大学齐鲁医院呼吸科,山东省济南市250012

出　　处：《中国临床康复》2006年第27期73-75,共3页Chinese Journal of Clinical Rehabilitation

摘　　要：目的:观察麻黄、白芍复方中药对急性加重期慢性阻塞性肺疾病患者肺功能和血清中细胞因子水平的影响。方法:①选择2002-09/2003-09山东大学齐鲁医院呼吸科就诊的急性加重期慢性阻塞性肺疾病患者60例。采用均衡随机法将患者分为2组:对照组30例(男19例,女11例)和治疗组30例(男18例,女12例)。均对治疗方案和检测项目知情同意。选择同期本院健康体检自愿者30人为健康组,男20人,女10人。对照组根据病情用常规疗法,治疗2～4周。治疗组在常规治疗基础上加用麻黄、白芍复方中药(组成:麻黄9g、白芍12g,法半夏12g,桂枝12g、五味子、甘草各6g,细辛、干姜各3g,大枣6枚,均来自山东大学齐鲁医院中药房),1剂/d,水煎,分2次服,疗程4周。②治疗前后采用肺功能仪测定肺通气功能(第1秒用力呼气量占预计值百分比)、呼吸阻抗(总气道阻力和共振频率)。采用双抗体夹心酶联免疫吸附法测定血清白细胞介素4、白细胞介素8、干扰素γ水平。③组间差异比较采用t检验。结果:急性加重期慢性阻塞性肺疾病患者60例和健康体检者30例均进入结果分析。①第1秒用力呼气量占预计值百分比:对照组和治疗组治疗前均明显低于健康组(t=4.53,4.47,P<0.01),治疗后较治疗前明显升高(t=3.8,5.09,P<0.05,0.01)。②总气道阻力、共振频率:对照组和治疗组治疗前均明显高于健康组(t=6.35～7.29,P<0.01),治疗后较治疗前明显下降(t=4.29～6.78,P<0.05～0.01)。③血清白细胞介素4水平:对照组和治疗组治疗前均明显低于健康组(t=5.53,5.75,P<0.01);治疗组治疗后明显高于治疗前和对照组治疗后(t=7.63,3.29,P<0.01,0.05)。④血清干扰素γ、白细胞介素8水平:对照组、治疗组治疗前均明显高于健康组(t=9.21～10.37,P<0.01);治疗组治疗后明显低于治疗前和对照组治疗后(t=5.05～9.17,P<0.05～0.01)。结论:麻黄、白芍药复方中药可改善急性加重期�AIM：To observe the effect of compound ephedra and white peony decoction on the pulmonary function and serum cytokines in patients with acute exacerbation chronic obstructive pulmonary diseases （AECOPD）. METHODS： ① Sixty patients with AECOPD were selected from Department of Pulmonary Medicine, Qilu Hospital of Shandong University from September 2002 to September 2003. They were randomly divided into two groups： control group （n=30, including 19 males and 11 females） and therapy group （n=30. including 18 males and 12 females）. Meanwhile 30 healthy volunteers, who underwent physical examination and consisted of 20 males and 10 females, were taken as the normal control group. They all knew and agreed to the therapy scheme and detection items. The control group was treated with conventional therapy for 2-4 weeks. And the treatment group was treated with conventional therapy combined with compound ephedra and white peony decoction （composing： 9 g ephedra, 12 g white peony, 12 g rhizoma pinellinae praeparata, 12 g cassia twig, 6 g Chinese magnoliavine fruit, 6 g glycyrrhizia, 3 g siebold wildginger herb, 3 g dried ginger and 6 jujube, and all were provided by Department of Traditional Chinese Medicine, Qilu Hospital of Shandong Province）, one preparation per day in twice water decoction. The course duration was 4 weeks.②Changes of serum interleukin （IL） 4, IL 8 and interferon （IFN） γ of AECOPD patients were determined with enzyme-linked immunoabsorbant assay （ELISA） method before and after treatment respectively. Meanwhile the percentage of pulmorlary ventilation function [forced expiratory volume in the first second （FEV1）/anticipated value （FEV1/pred）] and respiration impedance [total airway resistance value （RS） and resonance frequency value （Fres）] were measured by the pulmonary function meter. ③The difference of calculation results between groups was compared with the t test. RESULTS：All the 60 AECOPD patients and 30 healthy physical examinees were in

关 键 词：肺疾病 慢性阻塞性/中药疗法 呼吸功能试验 干扰素Ⅱ型 白细胞介素4 白细胞介素8 

分 类 号：R563[医药卫生—呼吸系统]